Prospective Study : Helicobacter Pylori Eradication Therapy in Accordance With Past Antibiotics Use
Phase 4
- Conditions
- Helicobacter Eradication
- Interventions
- Drug: Helicobacter pylori eradication
- Registration Number
- NCT01938534
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
Prospective study : Helicobacter pylori eradication therapy in accordance with past antibiotics use.
- Detailed Description
Antibiotics resistant is serious problem in helicobacter pylori eradication. Clarithromycin is very important antibiotics in eradication. But clarithromycin resistance is increased. Major cause of clarithromycin resistance is past consumption of macrolide. Thus the investigators propose eradication of macrolide used group bismuth contained four drugs therapy.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 440
Inclusion Criteria
- Peptic ulcer disease
- Gastric MALT lymphoma
- Early gastric cancer
- Familial history of gastric cancer
- Idiopathic iron deficiency
- Chronic idiopathic thrombocytopenia
- Atrophic gastritis
- Helicobacter infected dyspepsia
- Long term NSAIDs use
Exclusion Criteria
- Pregnant
- Previous proton pump inhibitor, antibiotics or anticoagulant use within 2 weeks
- Previous stomach surgery
- Severe ill patients (heart failure, hepatic failure, renal failure, hematologic disorder, severe psychologic or neurologic disorder)
- Previous Helicobacter eradication
- Allergy for Helicobacter eradication medicine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental Helicobacter pylori eradication Omeprazole 30mg twice Clarithromycin 500mg twice Amoxicillin 1000mg twice for 10 days Control Helicobacter pylori eradication Tetracycline 500mg four times Omeprazole 30mg twice Bismuth 600mg twice Metronidazole 500mg three times for 10 days
- Primary Outcome Measures
Name Time Method Eradication rate of Helicobacter pylori one month
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of