Identifying DAPT responsiveness with Ayurgenomics approach

Not Applicable

Conditions: Health Condition 1: I22- Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Registration Number: CTRI/2020/02/023092

Lead Sponsor: A

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. North Indian ethnicity

2. CAD patients (stable angina, non ST elevation and ST elevation myocardial infarction) presenting to Cardiology OPD, AIIMS after 30days of PCI up to 180 days

3. Patients receiving dual antiplatelet therapy and on stable dose of clopidogrel upto 150 mg once a day and aspirin upto 150 mg once a day for a minimum period of 30 days

4. Willing to participate in the study

Exclusion Criteria

1. Patients under anti coagulation therapy

2. Use of intensified antiplateletagents other than standard dual antiplatelet therapy

3. h/o Bleeding disorders (Hemophilia, von Willebrand disease), hospitalization related to bleeding

4. Chronic kidney disease (eGFR < 60 ml/min)

5. Any contraindications if elicited to antiplatelet therapy

6. Patients with hemoglobin < 10

7. Patients with platelet count < 100K

8. Patients with major surgery within 1 week

9. Patients with regular need of NSAID or prednisone(not taken in past 2 weeks)

10. Females with pregnancy or lactation

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Primary outcome - <br/ ><br>Association of gene polymorphisms with Prakriti types among the responders and non responders as categorized by Light transmission aggregometry test in north Indian CAD patients receiving dual antiplatelet therapy <br/ ><br> <br/ ><br>2. Co-primary outcome - <br/ ><br>Association between Prakriti types and the responders and non responders as categorized by Light transmission aggregometry test in north Indian CAD patients receiving dual antiplatelet therapy <br/ ><br>Timepoint: cross sectional study, data will be recorded/collected once only

Secondary Outcome Measures