Safety and Efficacy of Natalizumab in Combination With Remicade in the Treatment of Crohn's Disease
- Conditions
- Crohn's Disease
- Registration Number
- NCT00055536
- Lead Sponsor
- Biogen
- Brief Summary
The purpose of this study is to determine the safety, tolerability, and efficacy of natalizumab in individuals diagnosed with active Crohn's Disease that are not in remission (CDAI greater than/equal to 150) and are currently taking Remicade. It is thought that natalizumab may stop the movement of certain cells, known as white blood cells, into bowel tissue. These cells are thought to cause damage in the bowel leading to the symptoms of Crohn's disease.
Patients who complete this study may be eligible for long-term natalizumab therapy via extension protocol ELN100226-351.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (18)
Digestive Disease Associates
🇺🇸Gainesville, Florida, United States
Borland Groover Clinic
🇺🇸Jacksonville, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
University of Kentucky Medical Center
🇺🇸Lexington, Kentucky, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Mercury Street Medical
🇺🇸Butte, Montana, United States
Long Island Clinical Research Associates, LLP
🇺🇸Great Neck, New York, United States
Asheville Gastroenterology
🇺🇸Asheville, North Carolina, United States
Wake Research Associates
🇺🇸Raleigh, North Carolina, United States
Boice-Willis Clinic
🇺🇸Rocky Mount, North Carolina, United States
Scroll for more (8 remaining)Digestive Disease Associates🇺🇸Gainesville, Florida, United States