Changes in Blood Measured Before, During and After Exercise in Heart Transplant Recipients. Imminently Effect of Interval Training With High Intensity Compared With Continuous Moderate Intensity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Changes in ICAM levels with interval training compared to moderate training
研究概览
简要总结
High intensity Interval training (HIT) has repeatedly been documented to have superior positive effects on oxygen uptake and general physical health compared to continuous moderate exercise in healthy individuals and patients with heart disease. Recently, the same effect has been shown in heart transplanted recipients. Which mechanisms that explains this difference is uncertain; the effect can be due to changes in the heart or changes in the peripheral tissue and muscles. To explore these mechanisms the investigators will in this study compare two different exercise modalities, and explore how different biomarkers change in blood, related to exercise.
详细描述
15 heart transplanted recipients (and 5 healthy controls) will be included in the study. Each patient will have three study-days.
The study is designed to be a cross-over study. And randomisation will decide which training they will have som training session 1 and training session 2; Interval or continuous training.
Before starting the two training sessions they will measure oxygen uptake and baseline blood samples.
During each exercise session the patients will take blood samples during and after exercise.
After first study admission the patients will have a wash out period for 1 week until first training session, and another week until the last session.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1-10 years after heart transplantation
- •Lives in Oslo or near Oslo
- •Stable health condition
- •Optimal medical treatment/ medication
- •No limiting physical handicap
- •Written consent
- •Inclusion healthy control:
- •No verified heart disease
- •Willing to preform the study
- •Over 18 years
- •Written consent
排除标准
- •Under 1 year or over 10 year since HTx.
- •Lives far from Oslo
- •Unstable health condition
- •Not optimal medical treatment and/ or medication
- •Limiting physical handicap
- •Under 18 years
- •Not written consent
结局指标
主要结局
Changes in ICAM levels with interval training compared to moderate training
时间窗: 1 week
Changes in crp with interval training compared to moderate training
时间窗: 1 week
Changes in interleukin levels with interval training compared to moderate training
时间窗: 1 week
Changes in MiRNA levels with interval training compared to moderate training
时间窗: 1 week
次要结局
- Questionnaire of physical activity(baseline)
- Questionnaire of quality of life(baseline)
- Oxygen uptake(baseline)
研究者
Marianne Yardley
MD, PhD candidate
Oslo University Hospital