Muscle Thickness and Echogenicity in Post-Stroke Spasticity: A Comparative Study Between Early and Chronic Post-Stroke patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Mean difference in ultrasound-measured muscle thickness and echogenicity
研究概览
简要总结
Post-stroke spasticity leads to stiffness and weakness in the affected limbs, often resulting in difficulty walking and using the arm. This study aims to understand how muscle thickness and muscle quality (echogenicity) change over time after stroke. Using ultrasound, we will measure selected upper and lower limb muscles in two groups of stroke survivors: early stage (3–6 months) and chronic stage (>6 months). We will also record spasticity severity, motor function, grip strength, walking speed, and balance. The goal is to find whether muscle changes are worse in chronic stroke and how they relate to functional performance. Results may help design better rehabilitation programs and use ultrasound as a simple bedside tool to monitor recovery.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 78.00 Year(s)（—）
- 性别
- All
入选标准
- •First-ever ischemic or hemorrhagic stroke confirmed by imaging more than months post-stroke at time of assessment Clinically evident spasticity Modified Ashworth Scale more than one in at least one upper or lower limb Ability to ambulate (with or without assistance) Ability and willingness to provide informed consent.
排除标准
- •Cognitive impairment Severe medical instability or pregnancy History of phenol injection within past 2 years or botulinum toxin injection within past 3 months Presence of intrathecal baclofen pump Pre-existing neuromuscular or musculoskeletal disorders affecting limb function Uncontrolled pain or orthopedic deformity interfering with assessment.
结局指标
主要结局
Mean difference in ultrasound-measured muscle thickness and echogenicity
时间窗: cross sectional study ,only one point
次要结局
- Correlation between ultrasound parameters & spasticity severity(Obervational study ,only one point baseline)
- Correlation between ultrasound parameters & motor impairment(Obervational study ,only one point baseline)
- Association between ultrasound parameters & functional performance(Grip Strength measured with handheld dynamometer in kilograms, Timed Up & Go recorded in seconds, 6 Minute Walk Test measured in meters)
研究者
Dr Nitesh Manohar Gonnade
All India Institute of Medical Sciences (AIIMS), Jodhpur