The Safety and Effectivness of Quercetin and Dasatinib on the Epigenetic Aging Rates in Healthy Individuals
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Epigenetic Age Test
研究概览
简要总结
Assessing the effects of Quercitin and Dasatinib over a 16 week period on participatns' epigenetic biological aging. The patients are being tested at baseline, halfway point, and after the trial period.
详细描述
This is a prospective non-randomized clinical study of 20-25 patients to evaluate the effectiveness of Quercetin and Dasatinib supplements on the patient's epigenetic aging rate. The investigators predict that Quercetin and Dasatinib combined will slow cell proliferation and thus decelerate the rate of aging.
There is evidence that Quercetin and Dasatinib slows cell proliferation and decelerates aging and the risk of age-related diseases. The aim of this pilot study is to evaluate the safety, efficacy and feasibility of Quercetin and Dasatinib as an effective treatment option to improve clinical care of healthy individual's epigenetic aging rate thus prolonging longevity.
Despite considerable effort, successful treatment of reversing one's biological age has been shown to be a difficult therapeutic challenge. There is evidence that Dasatinib+Quercetin(Quercetin and Dasatinib) is a safe and effective treatment option to improve clinical care of healthy individual's biological age. Studies have shown that Dasatinib+Quercetin slows cell proliferation and decelerates aging and the risk of age-related diseases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women
- •Ages 40 and older
- •Patient must be able to comply with treatment plan and laboratory tests
排除标准
- •Neoplastic cancer within 5 years prior to screening, except for cutaneous basal cell or squamous cell cancer resolved by excision
- •No immune system issues or immunodeficiency disease
- •No history of viral illness which could be reactivated by immune down regulation
- •Presence of clinically significant acute or unstable cardiovascular and cerebrovascular (stroke)
- •Diagnosis of a transient ischemic attack in the 6 months prior to screening
- •Patients infected with hepatitis, C or HIV
- •Patients with Body Mass Index (BMI) > 40 kg/m2
- •Presence of active infection
- •Any other illness, psychiatric disorder, alcohol or chemical dependence that in the opinion of the investigator would render a patient unsuitable to participate in the study
- •Unable or unwilling to provide required blood sample for testing
- •As for the male-participants they are recommended to avoid fertilization for the first 6 months after the clinical trial.
- •If the patient has previously used Quercetin and Dasatinib.
研究组 & 干预措施
Quercetin and Dasatinib supplements
500mg Quercetin and 50mg Dasatinib oral capsules on Monday, Tuesday, Wednesday (3 days in a row) per month for the duration of 6 months.
干预措施: Dasatinib plus Quercetin (Drug)
结局指标
主要结局
Epigenetic Age Test
时间窗: Change from baseline to 6 months
次要结局
- Examining Methylation changes(Change from baseline to 6 months)