NCT01712464已完成不适用
Modulation of Reinforcement Learning and Neuronal Activation in Ventral Stratum by Oxytocin - a Pilot Study at Autism Spectrum Disorder
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Bold Signal in nucleus accumbens
研究概览
简要总结
This study aims to examine the modulation of neuronal and behavioural parameters of social reinforcement learning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 26 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 26 years
- •written informed consent
- •proband understands character, extent and individual consequences of the study
- •competent persons who are able to follow the instructions of the study personnel
- •for ASD patients: assured ASD diagnosis, comply of the ASD criteria ADI-R/ADOS-G
排除标准
- •prosopagnosia
- •anaphylaxis of oxytocin or other chemical substances
- •metal inside the body or other contraindications of mri scan
- •physical illness which can affect the examinations or endanger the proband
- •actual or assumed drug or alcohol abuse
- •persons who are accommodated in an institution because of court or administrative order
- •persons with a relationship of dependence to the sponsor or investigator
- •healthy probands: psychiatric disorder according to ICD-10-WHO F at the moment and in history, continuous drug-intake at time of measurements
- •patients with ASD: psychiatric disorder according to ICD-10-WHO F (except ASD disorder in patient group) during the last 12 month being not treated, continuous drug-intake at time of measurements (psychotropic medication), exception: stimulants used for treatment of attention disorders, if they can come off for the measurements
研究组 & 干预措施
Cross over Oxytocin and Placebo
Other
FMRI measurement and blood examinations after 26 IU Oxytocin (Syntocinon)or placebo on two consecutive days
干预措施: Oxytocin vs. Placebo (Drug)
Cross over Placebo and Oxytocin
Other
FMRI measurement and blood examinations after 26 IU Oxytocin (Syntocinon)or placebo on two consecutive days
干预措施: Oxytocin vs. Placebo (Drug)
结局指标
主要结局
Bold Signal in nucleus accumbens
时间窗: 1 Day
during social learning at one treatment with oxytocin vs placebo
次要结局
- Bold signal in ventral tegmental areal(1 Day)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Neuronal Responses to Social Feedback in Major Depressive DisorderMajor Depressive DisorderNCT02180607University of Michigan58
已完成
不适用
Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum DisordersSchizophreniform DisordersSchizophreniaSchizoaffective DisorderNCT04418011Centre for Addiction and Mental Health70
已完成
不适用
The neural mechanism of social reward and punishment anticipation in social anxiety disordersocial phobiasocial anxiety10002861NL-OMON33511niversiteit Leiden40
已完成
不适用
Neural Predictors of Social Emotion Regulation TrainingEmotionsRuminationNCT03487081Columbia University62
进行中（未招募）
1 期
Oxytocin for drug relapse preventiosubstance use disorderCTIS2023-504518-31-00Fondazione Santa Lucia IRCCS70