AMAP102 - Safety, Tolerability and Pharmacokinetics in Healthy Subjects

Phase 1

Terminated

• Conditions: Healthy Volunteers
• Interventions: Drug: AMAP102

• Registration Number: NCT00995605
• Lead Sponsor: AnaMar AB

Brief Summary

The purpose of this study is to determine whether AMAP102 is safe and well tolerated by humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-04
• Primary Completion: 2009-08
• Study Completion: 2009-08
• Status Verified: 2009-10
• Study First Submitted: 2009-10-13
• Study First Submitted QC: 2009-10-14
• Last Update Submitted: 2009-10-14
• Study First Posted: 2009-10-15
• Last Update Posted: 2009-10-15

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. In Groups A, B, D, E and F, subjects will be males of any ethnic origin between 18 and 65 years of with a BMI between 20.0 and 30.0 kg/m2
2. In Group C, subjects will be females (of non-childbearing potential) of any ethnic origin between 18 and 65 years with a BMI between 20.0 and 28.0 kg/m2
3. For Group C, women will be of non-childbearing potential, defined as surgically sterile or post-menopausal, non-lactating and having a negative serum pregnancy test
4. Subjects must be in good health, as determined by a medical history, physical examination, 12-lead ECG and clinical laboratory evaluations
5. Subjects will have given their written informed consent to participate in the study and to abide by the study restrictions

Exclusion Criteria

1. Male subjects who are not willing to use appropriate contraception from the time of the first dose until 3 months after the final dosing occasion
2. Subjects who have received any prescribed systemic or topical medication within 14 days of the first dose administration
3. Subjects who have used any non-prescribed systemic or topical medication within 7 days of the first dose administration
4. Subjects who have received any medications, including St John's Wort, known to chronically alter drug absorption or elimination processes within 30 days of the first dose administration
5. Subjects who are still participating in a clinical study or who have participated in a clinical study involving administration of an investigational drug in the past 3 months
6. Subjects who have donated any blood, plasma or platelets in the month prior to screening or who have made donations on more than two occasions within the 12 months preceding the first dose administration
7. Subjects with a significant history of drug allergy as determined by the Investigator
8. Subjects who have any clinically significant allergic disease as determined by the Investigator
9. Subjects who have a supine blood pressure and supine pulse rate higher than 140/90 mmHg and 100 beats per minute (bpm), respectively, or lower than 90/50 mmHg and 40 bpm, respectively
10. Subjects who consume more than 28 units (males) or more than 21 units (females) of alcohol per week or who have a significant history of alcoholism or drug/chemical abuse as determined by the Investigator (one unit of alcohol equals ½ pint [285 mL] of beer or lager, one glass [125 mL] of wine, or 1/6 gill [25 mL] of spirits)
11. Subjects who smoke more than 10 cigarettes or the equivalent in tobacco per day
12. Subjects with, or with a history of, any clinically significant neurological, gastrointestinal, renal, hepatic, cardiovascular, psychiatric, respiratory, metabolic, endocrine, haematological or other major disorders as determined by the Investigator
13. Subjects who have had a clinically significant illness within 4 weeks of the start of dose administration as determined by the Investigator
14. Subjects who are known to have serum hepatitis, or who are carriers of the HBsAg or hepatitis C antibody, or who have a positive result to the test for HIV antibodies
15. Subjects who have an abnormality in the 12-lead ECG such that, in the opinion of the investigator, increases the risk of participating in the study, such as QTc(b) interval greater than 430 msec (male) or greater than 450 msec (female), 2nd or 3rd degree Atrioventricular block, complete left bundle branch block, complete right bundle branch block or Wolff-Parkinson-White Syndrome, defined as PR shorter than 110 msec, confirmed by a repeat ECG
16. Subjects with a significant cardiac history (e.g. heart failure, hypokalemia, long QT syndrome), significant history of fainting, syncope or family history of sudden cardiac death
17. Subjects who, in the opinion of the Investigator, should not participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Groups SAD	AMAP102	AMAP102 or Placebo as single ascending doses in five groups
Groups MAD	AMAP102	AMAP102 or Placebo as multiple ascending doses twice daily for seven days in two groups

Primary Outcome Measures

Name	Time	Method
Safety and tolerability determined by adverse events, vital signs, ECG and clinical laboratory evaluations	During residential period and at follow up visit

Secondary Outcome Measures

Name	Time	Method
Investigate the pharmacokinetic profile of AMAP102 after one oral dose and after multiple oral doses during twice daily dosing for seven days, and compare the pharmacokinetic profile for men and women	PK sampling at defined timepoints during residential period

Trial Locations

Locations (1)

Covance Clinical Research Unit Ltd.; 🇬🇧 Leeds, United Kingdom