The Role Of The Glycocalyx And Magnesium In Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Withdrawn

Conditions: Subarachnoid hemorrhage
stroke
10007963

Registration Number: NL-OMON35997

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Subarachnoid hemorrhage with aneurysmal pattern on CT
or
xanthochromia of the cerebrospinal fluid and aneurysm demonstrated on angiography

Exclusion Criteria

Any chronic inflammatory condition
Perimesencephalic hemorrhage
Pattern of hemorrhage on CT not compatible with ruptured aneurysm
Body weight < 50 kg
Death is imminent
Hypermagnesemia on admittance (due to iatrogenic magnesium administration)
No informed consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To evaluate whether the endothelial glycocalyx is affected after SAH and in DCI<br /><br>and is related to severity of SAH.<br /><br>Differences in glycocalyx volume will be assessed by Sideview Darkfield (SDF)<br /><br>imaging as estimate of glycocalyx volume in patients with SAH and by<br /><br>measurement of glycocalyx constituents in plasma. DCI is diagnosed clinically,<br /><br>excluding other causes of neurologic deterioration. Severity of SAH is defined<br /><br>by the WFNS score.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Association between gylocalyx volume and administration MgSO4 in SAH<br /><br>- Association between glycocalyx perturbation in SAH and vasomotion changes as<br /><br>non-invasively assessed by finger arterial waveform registration.<br /><br>- Association between glycocalyx perturbation and blood pressure<br /><br>- Association between glycocalyx perturbation and clinical outcome, defined by<br /><br>the Rankin scale 3 months after the SAH. The Rankin scale is a 6-point handicap<br /><br>scale that focuses on restrictions in lifestyle.<br /><br>- Association between glycocalyx perturbation and endothelial damage, platelet<br /><br>activation, thrombin generation and fibrinolytic activity</p><br>