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临床试验/NCT05895526
NCT05895526尚未招募不适用

Comparison of the Clinical Effectiveness of Self Etch Adhesive and Fluoride Varnish in Reducing Dentin Hypersensitivity in Patients With Gingival Recession: Randomized Clinical Trial

Prime Foundation1 个研究点 分布在 1 个国家目标入组 142 人开始时间: 2023年6月12日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
142
试验地点
1
主要终点
Comparison of the clinical effectiveness of self etch adhesive and fluoride varnish in reducing dentin hypersensitivity in patients with gingival recession. A Randomized Clinical Trial

研究概览

简要总结

Comparison of the clinical effectiveness of self etch adhesive and fluoride varnish in reducing dentin hypersensitivity in patients with gingival recession. A Randomized Clinical Trial

ABSTRACT Objective: To compare the clinical effectiveness of self etch adhesive and fluoride varnish in reducing dentin hypersensitivity in patients with gingival recession

Study Design: Randomized Clinical Trial Place of Study: Department of Operative Dentistry and Endodontics, Peshawar Dental College, Warsak Road.

Methodology: 142 diagnosed cases of Dentin hypersensitivity from outpatient department of nephrology, Prime Hospital Peshawar will be referred to operative department, Peshawar dental college for Comparison of the clinical effectiveness of self etch adhesive and fluoride varnish in reducing dentin hypersensitivity in patients with gingival recession.

Results:

Conclusion:

详细描述

Dentin hypersensitivity is a common disorder and is one of the most irritating clinical condition1. It is one of the everyday complaints from patient visiting dental operatory2. Dentin hypersensitivity has been defined as "Short, sharp pain arising from exposed dentin in response to stimuli typically thermal, evaporative , tactile , osmotic or chemical that cannot be related to any other dental defect or pathology"3'4.Prevalance of dentin hypersensitivity in general population is 4% to 57% 5. Adults are normally affected by dentin hypersensitivity mainly in their late 30s however mainly people aged between 29 to 49 years can also suffer from this6.

One of the most well known theory for dentin hypersensitivity is Brannstorm and Astrom's Hydrodynamic theory2'6. According to this theory environmental ,thermal, chemical changes cause the movement of fluid within tubules, which stimulate terminals of pulpal nerve fibers located in tubules, this will lead to acute transient pain6'7.

Dentin is composed of dentinal tubules and dentin is protected by highly mineralized structures i.e enamel covers the dentin in crown portion while root dentin is protected by cementum8.Certain type of physical, chemical, pathological and biological challenges or developing defects can lead to exposure of dentin. Periodontal tissue loss or gingival recession is one of the most predisposing factor because it will lead to exposure of cervical and root dentin2.

A lot of research has been done on treatment of dentin hypersensitivity but still no consensus has been reached on which product is "gold standard" for treatment of dentin hypersensitivity9.Lukomsky suggested that fluoride can be used as topical desensitizing agent for reduction of DH. It has been in use since 1941.Fluoride causes formation of calcium fluoride crystals and varying degree of fluorapatite which will block the transmission of noxious stimuli to pulp. For treatment of dentin hypersensitivity varnishes containing sodium fluoride as an active component are in use for many years9.Some researchers recommended the use of self etch adhesive for reduction of dentin permeability10.Self etch adhesive form acid resistant hybrid layer due to which they show high level of clinical effectiveness. Yu et al showed that one bottle self etch adhesive plays an effective role in alleviating symptoms of dentin hypersensitivity11.

The aim of current clinical study is to compare clinical effectiveness of self etch and fluoride varnish in reducing dentin hypersensitivity in patients with gingival recession.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
20 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Patient with dentin hypersensitivity due to gingival recession.
  • Patients having Miller's Class 1 gingival recession.
  • Patient aged between 20-45yrs with gingival recession without other periodontal issues.
  • Patient without root filled teeth.
  • Patients who are willing to participate in the study.

排除标准

  • Teeth with extensive gingival recession.
  • Teeth with cervical restoration.
  • Pregnant and lactating mother.
  • Crowned teeth.

结局指标

主要结局

Comparison of the clinical effectiveness of self etch adhesive and fluoride varnish in reducing dentin hypersensitivity in patients with gingival recession. A Randomized Clinical Trial

时间窗: Two months

Patients will be divided into two groups. The Group 1 will receive the treatment that is based on the fluoride varnish company's instruction whereas Group 2 patients will under treatment regimens based on self etch dentin adhesive company's instructions.A clinical evaluation of each tooth will be done by another investigator who will not be involved with the treatment procedure. Air stimulation response measurement will be done via Visual analogue scale with score 0( No pain) ,1 2 3 ( Mild pain) , 4 5 6 (Moderate Pain) , 7 8 9 10 (Severe pain).The baseline evaluation (T0) before intervention , on the day of intervention after application of agents(T1), after one week (T2) and one month after treatment (T3) using tactile and air blast stimuli.The same examiner will calculate the total Visual analogue scale score of each study group at each follow up time from the mean of Visual analogue scale scores of all treated teeth of every subject in the same group..

次要结局

未报告次要终点

研究者

发起方
Prime Foundation
申办方类型
Other
责任方
Principal Investigator
主要研究者

Iftikhar Akbar

Professor

Prime Foundation

研究点 (1)

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