Prednisolone for loss of smell after COVID-19 infectio

Phase 4

• Conditions: Persistent (>1 month) loss of smell within 3 months of COVID-19 (SARS-CoV-2 infection) diagnosis based on a positive test; Infections and Infestations

• Registration Number: ISRCTN70794078
• Lead Sponsor: niversity Medical Center Utrecht

Brief Summary

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36384737/ (added 18/11/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-06-09
• Last Update Posted: 28 November 2022
• Study Completion: 2024-03-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

1. Recent COVID-19 infection (<3 months), confirmed with a positive test
2. Persistent loss of smell after 1 month, objectified by threshold-discrimination-identification (TDI) <30.5 on Sniffin’ Stick test
3. Age 18 years or older, capable of giving informed consent

Exclusion Criteria

1. Pre-existing olfactory disorders
2. Chronic rhinitis or rhinosinusitis (with or without nasal polyps)
3. Pregnancy
4. Corticosteroids (nasal, oral or intravenously) in last month
5. Contra-indications of steroid use:
5.1. Insulin dependent diabetes mellitus
5.2. Ulcus pepticum

Study & Design

• Study Type: Interventional
• Study Design: Not specified