ACE inhibitors to augment the effects of pulmonary rehabilitation in COPD

Not Applicable

Completed

• Conditions: COPD; Respiratory; Chronic obstructive pulmonary disease, unspecified

• Registration Number: ISRCTN79038750
• Lead Sponsor: Imperial College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11-29
• Last Update Posted: 28 November 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Adults with GOLD stage II-IV COPD and a clinical indication for pulmonary rehabilitation (MRC score of 3 or more or functionally limited)

Exclusion Criteria

1. Clinically unstable patients (within one month of exacerbation)
2. Those with a permanent pacemaker (which is a contraindication to magnetic stimulation), or significant co-morbidity
3. Patients with an accepted indication for ACE inhibition (left ventricular dysfunction, diabetes) or a contraindication such as renovascular disease
4. Creatinine clearance (estimated) <50)
5. Hypotension
6. Use of anticoagulants (contra-indication to biopsy) or ACE-I or ATII receptor antagonists
7. Allergy to ACE-inhibitors
8. Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified