Different Antihypertensive Drugs on Aortic Diseases

Completed

• Conditions: Aortic Aneurysm; Aortic Dissection
• Interventions: Drug: CCB use; Drug: non-CCB use

• Registration Number: NCT06626607
• Lead Sponsor: Eighth Affiliated Hospital, Sun Yat-sen University

Brief Summary

The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is:

Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

Detailed Description

This study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. The study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the Eighth Affiliated Hospital and Beijing Anzhen Cardiothoracic Surgery Center. Patients were assigned based on the postoperative antihypertensive medication regimens. Datas was collected to compare the cardiovascular-related prognoses.

This study primarily includes patients who take oral antihypertensive medications after aortic surgery. The main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. Multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2024-05-30
• Study Completion: 2024-09-30
• Study First Submitted: 2024-09-30
• Status Verified: 2024-10
• Study First Submitted QC: 2024-10-02
• Last Update Submitted: 2024-10-02
• Study First Posted: 2024-10-04
• Last Update Posted: 2024-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 704

Inclusion Criteria

• aortic diseases' patients underwent aortic surgery who require antihypertensive medication.

Exclusion Criteria

• Patients with active vasculitis;
• Patients allergic to contrast agent
• Patients with aorta variation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
CCB group	CCB use	Patients' postoperative antihypertensive includes CCB (Calcium Calcium Entry Blockers)
non-CCB group	non-CCB use	Patients' postoperative antihypertensive does not include CCB

Primary Outcome Measures

Name	Time	Method
Aortic diameter	Through the study completion, on an average of 3 years	The maximum diameter of the aorta measured by computed tomography angiography

Secondary Outcome Measures

Name	Time	Method
Number of Participants with adverse aortic event	Through the study completion, on an average of 3 years	Postoperative adverse aortic event during follow-up, including aortic related death or reoperation