NCT00483392已完成不适用
Treatment of Hyperglycaemia and Insulin Resistance in HIV Infected Patients
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- fasting plasma glucose, basal insulin levels
研究概览
简要总结
The purpose of this study is to evaluate and compare the effects of treatment with rosiglitazone and metformin on insulin resistance in patients infected with Human Immunodeficiency Virus on stable Highly Active Antiretroviral Therapy including a Protease Inhibitor after the period of 48 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •documented HIV infection
- •stable Protease Inhibitor containing HAART regimen for at least 12 months
- •impaired glucose tolerance
- •elevated insulin levels (above 20 mIU/l)
排除标准
- •patients already taking oral hypoglycaemic treatment or insulin
- •heart failure NYHA I-IV
- •liver disease or kidney disease
- •elevated AST or ALT above 2 times upper normal range
- •elevated creatinine (above 150 mmol/l)
结局指标
主要结局
fasting plasma glucose, basal insulin levels
时间窗: 48 weeks
次要结局
- insulin resistance, beta cell function(48 week)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
4 期
Insulin Glargine v Rosiglitazone as add-on Therapy in Patients Failing Sulfonylurea and Metformin Combination TherapyType 2 Diabetes MellitusNCT00358124Sanofi220
撤回
4 期
Study Protocol for Rosiglitazone Versus Gliclazide in Diabetics With AnginaAngina PectorisDiabetes Mellitus, Type 2NCT00225342University of Glasgow60
终止
不适用
Defining the Role of Insulin Resistance in 'Idiopathic' Dilated CardiomyopathyDilated CardiomyopathyNCT00466713Stanford University
已完成
2 期
Effect of Metformin and Rosiglitazone Over no Diabetic With Metabolic Syndrome Patients.Insulin ResistanceNCT04148183J JESUS VENEGAS, MD30
已完成
2 期
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II DiabetesCongestive Heart FailureNCT00064727National Heart, Lung, and Blood Institute (NHLBI)50