Topical Insulin in Treatment of Neurotrophic Corneal Ulcer,Efficacy And Safety
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- Assiut University
- Enrollment
- 14
- Primary Endpoint
- Decrease in ulcer size and the increase in visual acuity .
Study Overview
Brief Summary
To evaluate Safety and efficacy of topical insulin in treatment of neurotrophic corneal ulcers
Detailed Description
Neurotrophic keratopathy is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation. A reduction In corneal sensitivity or complete corneal anesthesia is the hallmark of this disease and is responsible for producing epithelial keratopathy, ulceration and perforation.
Because decreased corneal sensitivity is the hallmark sign of neurotrophic keratitis (NK), corneal sensitivity testing should be performed as soon as It is suspected
There are 2 common ways to test-one qualitative, the other quantitative:
The qualitative method is most commonly used In clinic and often achieved with a cotton tipped applicator because It is easily accessible.
The most common quantitative method is the handheld esthesiometer (Cochet-Bonnet).
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with neurotrophic corneal ulcers caused by:
- •Herpes simplex or Herpes zoster viral infection
- •Topical anesthetics abuse
- •Chemical and physical burn
- •Chronic CL wear
- •Following LASIK,PRK,CXL
- •Following vitrectomy and endophotocoagulation for retinal detachment
- •Diabetes mellitus
- •Trigeminal neuralgia surgery
Exclusion Criteria
- •Non compliant patients with the study protocol
Arms & Interventions
insulin eye drop
Intervention: insulin eye drops (Drug)
Outcomes
Primary Outcomes
Decrease in ulcer size and the increase in visual acuity .
Time Frame: baseline
To evaluate the effect of topical insulin eye drops in treatment of neurotrophic corneal ulcer.
Secondary Outcomes
No secondary outcomes reported
Investigators
Gehad Abd Elrahim Ahmed
Doctor
Assiut University