Is Flunarizine a Cheap, Well-Tolerated and Long-Acting Atypical Antipsychotic? A Randomized Double-Blind Flexible-Dose Clinical Trial Versus Haloperidol for the Treatment of Schizophrenia

Ambulatório de Bipolaridade2 个研究点分布在 1 个国家目标入组 70 人开始时间: 2004年9月1日最近更新: 2008年8月22日

适应症

试验速览

阶段: 4 期
状态: 已完成
发起方
入组人数: 70
试验地点: 2

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

Flunarizine is a calcium channel blocker traditionally used for the treatment of vertigo and migraine. It also has the mechanism of action associated with antipsychotic activity (D2 receptor blockade), but has never been tested as such. The investigators hypothesis is that flunarizine can be an atypical antipsychotic.

详细描述

The main advantage of flunarizine over other D2 receptor blockers is its long half-life, so that it may be administered weekly or may delay relapse if medication is interrupted.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围: 18 Years 至 60 Years（Adult）
性别: All
接受健康志愿者: 否

入选标准

•DSM-IV schizophrenic or schizoaffective patients between 18 and 55 years old with a PANSS score above 45.

排除标准

•Clinical disease
•Pregnancy
•Drug dependence (except for nicotine) in the past month and history of being refractory to at least 2 antipsychotics taken appropriately.

研究者

发起方

Ambulatório de Bipolaridade

申办方类型

Other

研究点 (2)

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