Skin physiological changes during the combination of daylight PDT with fractional laser therapy

Not Applicable

• Conditions: L57.0; Actinic keratosis

• Registration Number: DRKS00025590
• Lead Sponsor: Klinik für Dermatologie, Allergologie und Phlebologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-25
• Study Completion: 2022-07-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Men and women with actinic keratosis on the scalp

Exclusion Criteria

Men and women without actinic keratosis, pregnant women

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in skin physiological parameters on the forearm (TEWL, colorimetry, corneometry).<br> <br>P- patient - patient with actinic keratosis, skin of the forearm on the right or left.<br>I - Intervention - 4 fields on the forearm (daylight PDT, fractional laser, daylight, daylight PDT with the fractional laser)<br>C - Comparison - Each measurement is compared to the base measured value (time 0).<br>O - Outcome - skin physiological measured values ??as delta value to the base value 0 minutes (before intervention): <br>TEWL (barrier change, in g / m2 / h)<br>Colorimetry erythema (a-values, taken from the L * a * b * units)<br>Corneometry (skin moisture, in relative Corneometer® units)<br>The delta values ??of a measurement time (30 minutes, 24 hours, 7 days and 14 days) are always compared to the base value of 0 minutes.

Secondary Outcome Measures

Name	Time	Method
Reduction of actinic keratoses on the scalp under daylight PDT with the fractional laser.<br>P - patient - patient with actinic keratosis, scalp<br>I - Intervention - daylight PDT with the fractional laser (one side of the scalp)<br>C - Comparison - daylight PDT without fractional laser (the other side of the scalp)<br>O - Outcome - percent reduction in actinic keratosis<br> <br>Definition of the variables:<br>aKvTh = number of actinic keratoses before therapy (is clinically counted)<br>aKnTh = number of actinic keratoses after therapy (is counted clinically)<br>EbaKnTH = successfully treated actinic keratoses after therapy (will be calculated - see below)<br>RedaK = reduction of actinic keratoses in percent (is calculated - see below)<br> <br>EbaKnTH = aKvTh - aKnTh<br> <br>RedaK = EBAKnTH / aKvTh * 100