The effect of faecal transplant on insulin sensitivity in adults with pre-diabetes and diet-controlled diabetes

Not Applicable

Not yet recruiting

• Conditions: Diabetes; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12616001094460
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Eligibility criteria will be:
Body mass index (BMI) of 25 kg/m2 or greater.
Aged 18 years or above.
Fasting blood glucose >6.0 mmol/L or HbA1c >40 mmol/mol
Not taking any glucose lowering medications

Exclusion Criteria

Anyone lacking mental capacity to provide informed consent.
Prebiotic/probiotic supplements or antibiotics in the last 3 months.
Past cholecystectomy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome will be insulin sensitivity assessed by homeostatic model assessment (HOMA-IS) and oral glucose tolerance test-based insulin sensitivity (OGIS). [Post-FMT days 3, 7, 14, 21, 28<br>Post-FMT weeks 6, 8, 12]

Secondary Outcome Measures

Name	Time	Method
Body weight by digital scales[Post-FMT days 3, 7, 14, 21, 28<br>Post-FMT weeks 6, 8, 12];Fasting glucose by serum assay[Post-FMT days 3, 7, 14, 21, 28<br>Post-FMT weeks 6, 8, 12];Oral glucose tolerance test by serum assay[Post-FMT weeks 6 and 12];HbA1c by serum assay[Post-FMT week 12]