Bolus dosages of Norepinephrine,phenylephrine and ephedrine for spinal induced Hypotension in parturients undergoing elective caesarean section.
Not Applicable
- Conditions
- Health Condition 1: O30-O48- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Registration Number
- CTRI/2020/06/025626
- Lead Sponsor
- S NIJALINGAPPA MEDICAL COLLEGE AND HSK HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age between 18 to 35 years.
2.Body mass index <=30 kg/m2
3.Singleton pregnancies at term scheduled for
elective cesarean section under
spinal anesthesia
Exclusion Criteria
1.ASA status III and IV.
2.Emergency caesarean section.
3.Active labour.
4.High risk pregnancies ( Intrauterine growth
retardation, preeclampsia)
5.Maternal cardiovascular and pulmonary
diseases.
6.Foetal abnormalities
7.History of diabetes excluding Gestational diabetes
8.Patients on MAO inhibitors and TCA.
9.Patients allergic to any of the medications used in study.
10.If block(anesthesia) level achieved higher than T4.
11.Height less than 140cm or more than 180cm
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy(potency) and safety of bolus dosages of Norepinephrine, Phenylephrine, Ephedrine in elective parturient women to treat hypotension during caesarean delivery under spinal anaesthesia. <br/ ><br>Timepoint: Number of blous dosages of drug needed to treat maternal hypotension,number of episodes of maternal hypotension occurred before delivery of baby and fetal outcomes immediately after birth (to prove most potent and effective drug to treat maternal hypotension intra operatively 1st 12 minutes following performing spinal anaesthesia)
- Secondary Outcome Measures
Name Time Method 1.Assessing number of episodes of bradycardia (HR less than60 bpm), tachycardia (HR less than 120 bpm) hypertension(SBP greater than20% of baseline) and number of hypotension episodes occurred. <br/ ><br>2.Assessing number of vasopressor boluses required to treat post spinal hypotension <br/ ><br>3. Assessing maternal side effects like nausea, vomiting, dizziness and shivering. <br/ ><br>4.Assessing neonatal outcome, including Apgar scores at one minute and five minutes, umbilical artery blood gas analysis and pH. <br/ ><br>Timepoint: 2 hours