The effect of melatonin on cognitive function, after coronary artery bypass grafting surgery.
Phase 2
- Conditions
- Coronary Artery Bypass Grafting Surgery..Atherosclerotic heart disease of native coronary arteryI25.1
- Registration Number
- IRCT20141009019470N77
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Patients aged 40-75 years
Patients who are undergoing elective Cardio pulmonary artery bypass grafting.
Exclusion Criteria
Acute recent Myocardial Infarction (less than 3 month)
Aortic atheromatosis
Renal dysfunction;
Peripheral vascular disease;
Pump time more than 90 min;
Corticosteroid therapy since 1 month ago;
infection less than 4 weeks ago;
Breast feeding
Pregnancy;
Dementia;
Psychiatric disorders
Using Benzodiazepines and opioid;
Alcohol abuse
Hepatic insufficiency
Non sinus ECG;
Concomitant cardiac surgery;
Anticoagulation therapy with warfarin
ASA higher than 3
Ejection Fraction less than 45%
Severe pulmonary disease
Cerebrovascular disease
Immunologic disorders
Re-operation
Emergency operation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive function. Timepoint: 4 weeks before surgery,2 days after surgery and 6 weeks after melatonin administration. Method of measurement: Cognitive function Test.
- Secondary Outcome Measures
Name Time Method