Bevacizumab Intravitreal for Myopic Choroidal Neovascularization

Instituto de Olhos de Goiania1 site in 1 country5 target enrollmentJanuary 2007

ConditionsMyopic Choroidal Neovascularization

InterventionsInjection

DrugsInjection

Overview

Phase: Phase 4
Intervention: Injection
Conditions: Myopic Choroidal Neovascularization
Sponsor: Instituto de Olhos de Goiania
Enrollment: 5
Locations: 1
Status: Completed
Last Updated: 17 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

To evaluate the clinical results of anti-VEGF intra-vitreal injections (IVT) in CNV secondary to pathologic myopia (PM-CNV).

Detailed Description

Nineteen consecutive patients (19 eyes) with subfoveal PM-CNV, 18 of whom had been unsuccessfully treated with Visudyne PDT, were treated with IVT of 1.25 mg bevacizumab or 0.5mg ranibizumab. ETDRS best corrected visual acuity, macular thickness on OCT scans, and angiographic features were recorded and evaluated. The aspect of OCT scans passing across the PM-CNV was also analyzed. IVTs were repeated only in case of persistent angiographic leakage and if OCT scans showed retinal thickening or edema and serous retinal detachment. The follow-up period was at least 6 months.

Registry

clinicaltrials.gov

Start Date

January 2007

End Date

November 2008

Last Updated

17 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Instituto de Olhos de Goiania

Eligibility Criteria

Inclusion Criteria

•Myopic CNVM,

Exclusion Criteria

•Patients with poor compliance
•Patients with uncontrolled diabetes and hypertension or any other medical condition that increase the risk of complications like recent history of Stroke or myocardial infraction (\< one year). (Physician clearance was obtained for all patients).
•Age related macular degeneration with Juxtafoveal and Subfoveal CNVM: Recurrent CNVM following PDT and TTT with IVTA. Patient who could not afford PDT, Macugen or Lucentis which is FDA approved.
•Patients who had undergone major surgery 28 days before, were excluded from the study and it was also suspended prior to elective surgery.
•Refractory macular oedema due to vein occlusion, Pseudophakia, Clinically significant macular oedema (CSME) etc. that affects vision and does not respond adequately to usual treatment methods.
•Proliferative diabetic retinopathy, non-resolving vitreous haemorrhage with PDR.
•Idiopathic CNVM, Inflammatory CNVM and other conditions associated with CNVM.