Wound healing in surgical trauma

Not Applicable

• Conditions: Patients with major trauma requiring surgery for a fracture to the lower limb.; Musculoskeletal Diseases; Major trauma

• Registration Number: ISRCTN12702354
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

1. 2018 protocol in https://www.ncbi.nlm.nih.gov/pubmed/29880575 2. 2019 statistical analysis plan in https://www.ncbi.nlm.nih.gov/pubmed/30922364 3. 2020 results in https://www.ncbi.nlm.nih.gov/pubmed/32044942 (added 12/02/2020) 4. 2020 results in https://pubmed.ncbi.nlm.nih.gov/32821038/ (added 25/08/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-09
• Last Update Posted: 7 September 2020
• Study Completion: 2023-04-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 1548

Inclusion Criteria

Current participant inclusion criteria (as of 18/12/2017):
1. Aged 16 years or older
2. Present to hospital within 72 hours of injury
3. Presence of major trauma (as defined by eligibility for the UK Trauma Audit Research Network (TARN) database)
4. Presence of a lower limb fracture requiring a surgical incision

Previous participant inclusion criteria:
1. Aged 16 years or older
2. Present to the trial hospital within 72 hours of injury
3. Presence of major trauma (as defined by eligibility for the UK Trauma Audit Research Network (TARN) database)
4. Presence of a limb fracture requiring a surgical incision

Exclusion Criteria

1. An open fracture of the lower limb which cannot be closed primarily
2. There is evidence that the patient would be unable to adhere to trial procedures or complete questionnaires

Study & Design

• Study Type: Interventional
• Study Design: Not specified