Treatment of Postoperative Delirium With Continuous Theta Burst Stimulation: an Exploratory Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Cure rate of POD after a single cTBS treatment
研究概览
简要总结
To determine whether continuous theta burst stimulation can cure postoperative delirium in senior patients.
详细描述
Postoperative delirium(POD), a syndrome characterized by an acute change in attention, awareness and cognition, is one of the most common postoperative complications among elderly patients. Impaired neuronal network connectivity is likely one of the several neurobiological processes that contribute to POD pathogenesis. Recently, continuous theta burst stimulation (cTBS) was demonstrated to improve cognitive function in patients with mild cognitive impairment.Recent research suggests that cTBS has positive effect on improving the connectivity and reorganization of the brain network. Therefore, we plan to conduct an exploratory study in participants undergoing elective surgeries to determine whether cTBS can cure POD in this senior patient population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged between 60 to 80 years;
- •Having delirium after elective surgery;
- •Being able to complete cognitive assessment and confusion assessment methods (CAM);
- •Willing to participate before surgery and being competent to provide informed consent.
排除标准
- •Having brain tumor, stroke, or mental disorders (e.g., depression or dementia);
- •Having contraindications of cTBS (e.g., head trauma, history of epilepsy or metal implants in the head or heart);
- •Participating in other clinical studies.
结局指标
主要结局
Cure rate of POD after a single cTBS treatment
时间窗: 7 days after surgery
No POD was evaluated by CAM at 1 hour after a single cTBS treatment on the day of the first occurrence of POD and at any time point thereafter.
次要结局
- Cure rate of POD after multiple cTBS treatments(7 days after surgery)
- Severity of postoperative delirium changed after each cTBS treatment(7 days after surgery)