The Effect of Sleep Apnea on Sleep Dependent Learning Using the Visual Discrimination Task.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- VDT learning Change Score
研究概览
简要总结
The purpose of this study is to determine whether obstructive sleep apnea affects sleep dependent memory and learning. Subjects with apnea will be given a test of perceptual skill learning (the Visual Discrimination Task (VDT)) that has previously been shown to depend on sleep. Subjects will be tested on this task before and after sleep. The difference in performance after sleep compared to before sleep provides a measure of sleep dependent learning. Participants will be tested on one night when they have less apnea because they are using continuous positive airway pressure (CPAP) as prescribed by their physician, which is well known to reduce apnea; and on another night when they are in their native state and have a greater degree of apnea. Memory performance will be compared between the two nights to determine how apnea affects sleep dependent memory.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of sleep apnea
- •Use PAP therapy as prescribed by his/her physician for 3-4 weeks prior to enrollment
- •Right-handed
排除标准
- •Major neurological or psychiatric condition
- •Chronic pain condition
- •Learning disabilities
- •Serious brain or head injury (e.g. seizure, stroke, head trauma)
- •Major surgery or general anesthesia in the past year
- •Pregnant or nursing
- •Problems with eyes or vision (besides corrected-to-normal with glasses or contacts)
- •Past diagnosis of infection that can affect the brain (e.g. meningitis, HIV/AIDS)
- •Medications that affect sleep (antidepressants, muscle relaxants, sleep aids, beta-blockers, stimulants, or corticosteroids)
- •Recreational drug use, including marijuana
- •Night-shift work
- •Cancer or cancer treatment in the last 2 years
- •Smoke more than 10 cigarettes per day
- •Consume more than 3 caffeinated foods or beverages per day
研究组 & 干预措施
Apnea patients on and off PAP in order A
Subject using usual positive airway pressure therapy while sleeping for one night, then crossing over to not using usual apnea therapy while sleeping for another night.
干预措施: Subject using usual positive airway pressure therapy while sleeping for one night (Other)
Apnea patients on and off PAP in order B
Subject not using apnea therapy while sleeping for one night, then crossing over and subject using usual positive airway pressure therapy while sleeping for one night.
干预措施: Subject using usual positive airway pressure therapy while sleeping for one night (Other)
结局指标
主要结局
VDT learning Change Score
时间窗: Change from baseline after 6-9 hours sleep
Learning on the visual discrimination task (VDT) is measured by comparing performance on the perceptual task at a baseline session prior to sleep to that in a second session after sleep. Subjects are standardly tested in the hour prior to their typical bedtime, and re-tested after spontaneously awakening after a night of sleep. Sleep is known to consolidate learning on this task, such that more robust learning occurs after an interval of sleep compared to when the patient is awake over the same interval (Stickgold et al, J Cog Neurosci,2000; Stickgold et al., Nat Neurosci, 2000). Our aim is to determine if sleep dependent learning is disrupted by apnea, and preserved when apnea is eliminated.
次要结局
- Apnea Hypopnea Index (AHI)(During minimum 6 hour sleep recording)
研究者
Heidi Roth, MD
Associate Professor of Neurology
University of North Carolina, Chapel Hill