NL-OMON24239招募中不适用
Fecal microbiota transplantation for improved Fructose catabolism and Insulin sensiTivity In patients with metabolic syndrome
Amsterdam UMC0 个研究点目标入组 48 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 48
研究概览
简要总结
n/a
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Inclusion criteria metabolic syndrome subjects:
- •Treatment naïve (no medication use)
- •Metabolic syndrome (3 out of 5 NCEP ATPIII criteria with at least fasting glucose = 5.6 mmol/l)
- •Aged 18-70 years
- •BMI = 25kg/m2
- •Low gut microbiome diversity in 3 baseline fecal samples taken during 1 week (average Shannon diversity 4.2 or lower)
- •Male/postmenopausal females
- •South Asian Surinamese (SAS) or Caucasian descent
- •Inclusion criteria fecal donors:
- •Treatment naïve (no medication use)
- •Normal fasting glucose and lipid levels
- •aged 18-70 years
- •BMI < 25kg/m2
- •Male / female gender
- •High microbiota diversity in 3 fecal samples taken during 1 week (average Shannon 4.2 or higher) with presence of
- •Desulfovibrio strains
- •South Asian Surinamese (SAS) or Caucasian descent
排除标准
- •Exclusion criteria metabolic syndrome subjects/donors:
- •Inability to provide written informed consent
- •Antibiotics use in the last 3 months and proton-pump inhibitor use
- •Alcohol or nicotine abuse
- •Evidence for compromised immunity
研究者
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