Prevalence of cardiac impairments after COVID-19

Conditions: U09.9
I41.1
Post COVID-19 condition, unspecified
Myocarditis in viral diseases classified elsewhere

Registration Number: DRKS00024992

Lead Sponsor: niversitätsklinikum Heidelberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 200

Inclusion Criteria

Age of at least 18 years and ability to consent
- COVID-19 at least 4 months ago - proven by SARS-Cov-2 PCR or antibody test

Exclusion Criteria

- Contraindications to MRI examinations - especially MRI incompatible implants, clinical instability and severe claustrophobia.
- Heart failure that existed prior to COVID-19
- Myocardial diseases (heart failure, cardiomyopathies, myocarditis) that existed prior to COVID-19
- Coronary artery disease, which requires or required coronary intervention and myocardial infarction.
- Prior cardiac surgery (e.g., bypass) and device implantation (e.g., heart valves, PFO occluders)
- Atrial fibrillation that existed prior to COVID-19
- Active cancer
- Pregnancy

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Changes in cardiac morphology (e.g. ventricular and atrial dimensions, myocardial mass)<br>- Changes in left and right ventricular ejection fraction<br>- Impairment of the global longitudinal strain, the long axis strains as well as segmental strains<br>- Proportion of myocardial segments with pathological strain values<br>- Changes in myocardial T1 and T2<br>- Changes in the 3D electrocardiogram

Secondary Outcome Measures

Name	Time	Method
- Changes in the subjective physical performance<br>- Occurence or persistence of COVID-19 associated symptoms<br>- Assessment of computer-based techniques for image analysis and diagnostics