ACTRN12624000554561
Recruiting
N/A
Prospective Study Evaluating The Treatment Outcomes For Localised Recurrent, Resectable Retroperitoneal Liposarcoma in adults.
Australia and New Zealand Sarcoma Association0 sites100 target enrollmentMay 1, 2024
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Retroperitoneal Liposarcoma (LPS)
- Sponsor
- Australia and New Zealand Sarcoma Association
- Enrollment
- 100
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged 18 years or older presenting with first recurrent well\-differentiated and/or dedifferentiated liposarcoma of retroperitoneal space or pelvis after previous macroscopically complete resection (R0/R1 resection)
- •2\. No distant metastasis on cross\-sectional imaging of chest/abdomen/pelvis (CT and/or MRI) within 1 month to confirm the absence of metastatic disease
- •3\. Previous histologically proven well\-differentiated or dedifferentiated liposarcoma histology only
- •4\. Sarcoma not originating from bone or abdominal or gynecological viscera
- •5\. Tumor confirmed to be resectable with likely R0/R1 resection, and all disease must be deemed to be treatable by RT (joint decision by surgeon and radiation oncologist at a sarcoma multidisciplinary team meeting)
- •6\. WHO performance status 0\-2
- •7\. American Society of Anaesthesiologist (ASA) score 1\-3
- •8\. No prior RT for the retroperitoneal liposarcoma
- •9\. Prior systemic therapy is allowed
- •10\. No concurrent active malignancy (except for low risk skin malignancy, low risk prostate carcinoma, low risk breast carcinoma including in situ disease)
Exclusion Criteria
- •1\. Unresectable disease or likely R2 resection as assessed by the multidisciplinary sarcoma team
- •2\. Extent of recurrence where preoperative RT to all visible disease is not deemed to be feasible
- •3\. Contradiction for RT such as history of bowel obstruction or mesenteric ischemia or severe chronic inflammatory bowel disease
- •4\. Myxoid liposarcoma histology
- •5\. Pregnancy
Outcomes
Primary Outcomes
Not specified
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