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Clinical Trials/NCT01126242
NCT01126242
Completed
Phase 4

Tape Versus Semirigid Versus Lace-up Ankle Support in the Treatment of Acute Lateral Ankle Ligament Injury.

Gelre Hospitals1 site in 1 country182 target enrollmentMay 2010

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Grade II and III Acute Lateral Ankle Ligament Injuries
Sponsor
Gelre Hospitals
Enrollment
182
Locations
1
Primary Endpoint
Karlsson score
Status
Completed
Last Updated
10 years ago

Overview

Brief Summary

The objective of this study is to compare tape versus semi rigid support versus lace up brace treatment for acute lateral ankle ligament injuries with regard to clinical outcome and cost effectiveness.

There is a difference of 10 in functional outcome (Karlsson Score) between non-elastic adhesive taping and semi-rigid and lace-up ankle support, in favour of the last, for the treatment of acute lateral ankle ligament injury at 6 months follow-up.

Detailed Description

This study is designed as a single blind prospective randomized controlled trial to evaluate the difference in functional outcome after treatment with tape versus semi-rigid versus lace-up ankle support (brace) for grade II and III acute lateral ankle ligament injuries. The patients will be randomly allocated into one of the three groups. Randomization will be performed by computer. Blinding of patients is not possible, but the observer will be blinded at eight weeks and six months.

Registry
clinicaltrials.gov
Start Date
May 2010
End Date
January 2015
Last Updated
10 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Gelre Hospitals
Responsible Party
Principal Investigator
Principal Investigator

Michel P. J. van den Bekerom

MD

Gelre Hospitals

Eligibility Criteria

Inclusion Criteria

  • Patients \> 18 years
  • Grade II or III ankle sprains
  • Presentation \< 72 hours after the acute injury

Exclusion Criteria

  • Patients with a history of chronic instability
  • Who had a fracture on X-ray investigation
  • Other injuries or disabilities on the same limb
  • Alcoholism, serious psychiatric and neurological illness
  • Patients with bilaterally sprained ankles
  • Patients with previous surgery on the lateral ankle ligaments
  • Skin diseases where taping is not practicable
  • Patients who are unable to give informed consent
  • Patients who are unable to fill out questionnaires
  • Neuromuscular disorders of the lower extremities

Outcomes

Primary Outcomes

Karlsson score

Time Frame: up to 6 months FU

The patients were asked to fill out a questionnaire regarding the function of the ankle joint. The score includes eight items based on a subjective evaluation of stability, pain, swelling and stiffness in relation to activities of everyday life, sports and recreational activities, running, stair climbing and working ability. The maximum score is 100 points.

Secondary Outcomes

  • Return to work(up to 6 months FU)
  • Return to sports(up to 6 months FU)
  • Pain VAS(up to 6 months FU)
  • Objective stability(up to 6 months FU)
  • Range of motion (ROM)(up to 6 months FU)
  • Recurrent inversion injury(up to 6 months FU)
  • Complications / adverse events(up to 6 months FU)
  • Tegner activity level(up to 6 months FU)
  • EuroQol (EQ5D)(up to 6 months FU)
  • Costeffectiveness(up to 6 months FU)
  • Compliance(up to 6 months FU)
  • FAOS(up to 6 months FU)

Study Sites (1)

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