se of neuromuscular monitoring to determine the muscle-specific potency of neuromuscular blocking agents

Conditions: vocal cords openingUpper abdominal laparotomyM17.1OPS: 5541.1
M17.1
Other primary gonarthrosis

Registration Number: DRKS00021433

Lead Sponsor: Katholisches Klinikum Bochum, Abteilung für Anästhesiologie und operative Intensivmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 154

Inclusion Criteria

• All genders
• Age = 18 years
• Elective surgery
• General anesthesia with administration of muscle relaxants
• Additional criteria depending on the part of the study:
Part A (vocal cord opening): intubation
Part B (diaphragm): upper abdominal laparotomy
Part C (lower leg muscles): knee surgery with tourniquet

Exclusion Criteria

• Neuromuscular diseases
• Allergy to muscle relaxants
• contractures on the fingers
• pregnancy
• Additional criteria depending on the part of the study:
Part A (vocal cord opening): indication for rapid sequence induction and (expected) difficult airway, hyperkalemia
Part C (lower leg muscles): amputation of the big toe on the side to be operated on, polyneuropathy, peripheral arterial disease (= stage 3)
• Patient rejects the study
• Simultaneous participation in another study
• Limited ability to provide information and consent, support

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Definition of a TOF value (indicated as a number by the relaxometry and derived from the hand), in which there is relaxation of a muscle or a muscle group (diaphragm, larynx muscle or muscles of the lower leg).

Secondary Outcome Measures

Name	Time	Method
• Deriving a dose of muscle relaxant that leads to relaxation of a specific muscle or muscle group<br>• Examination of possible influencing factors on the relaxation of the target muscles: type of muscle relaxant, age, gender, BMI, previous illnesses, medication