Hyperfibrinolysis in moderate to severe traumatic brain injury-related coagulopathy
Completed
- Conditions
- Traumatisch schedelhersenletselneurotraumaTraumatic Brain Injury (TBI)
- Registration Number
- NL-OMON37358
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
- Patients with moderate to severe traumatic brain injury
- Glasgow Coma Scale (GCS) score between 3 and 13 upon ED admission
- Age 18-75 years
Exclusion Criteria
- Patients with hemostatic deficiencies or previous hemostatic problems
- Prehospital traumatic cardiopulmonary resuscitation
- Emergency surgery in the hour following ED admission
- Absence of a peripheral intravenous catheter
- Patients using vitamin K antagonists, clopidogrel or dabigatran
- Pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Level of fibrinolysis using rotation thromboelastometry (ROTEM)<br /><br>- DIC using ISTH DIC scoring system (platelet count, D-dimer, prolonged PT and<br /><br>fibrinogen level)<br /><br>- Tissue hemoglobin oxygenation using near infrared spectroscopy (NIRS)<br /><br>- Endothelial barrier function will be analyzed in an Electric Cell-Substrate<br /><br>Impedance Sensing (ECIS) system </p><br>
- Secondary Outcome Measures
Name Time Method