The maximum tolerated dose of walking for people with osteoarthritis of the knee: a phase I trial

Phase 1

Completed

• Conditions: knee osteoarthritis; Musculoskeletal - Osteoarthritis; Physical Medicine / Rehabilitation - Physiotherapy

• Registration Number: ACTRN12614000098639
• Lead Sponsor: Jason Wallis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-01-28
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

(1) Adult aged at least 50 years and living independently in the community;
(2) diagnosed with moderate-to-severe knee osteoarthritis rated as grade III or IV;
(3) able to understand English;
(4) able to participate safely in the moderate-intensity physical activity trial using the 7-item Physical Activity Readiness Questionnaire.

Exclusion Criteria

(1) live in supported accommodation such as a nursing home;
(2) they report their daily resting level of pain to be 9 or 10 on an 11 point Numerical Pain Rating Scale. This level of pain may be indicative of a more serious pathology such as acute or inflammatory condition;
(3) high or very high levels of psychological distress as measured by the Kessler 10 questionnaire with a K10 score > 21;
(4) have an intellectual or mental impairment as measured by the Short Portable Mental Status Questionnaire with a score of 7 or less;
(5) have a systemic arthritic condition such as rheumatoid arthritis;
(6) have a neurological condition such as Parkinson’s disease or stroke that affects walking;
(7) had knee surgery or intra-articular corticosteroid injection within past six months;
(8) currently (within four weeks) using oral corticosteroids.

Study & Design

• Study Type: Interventional
• Study Design: Not specified