Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Wound healing will be assessed in both the experimental and control groups.
研究概览
简要总结
The goal of this clinical trial is to learn if the laser works to improve wound healing and bone regeneration after tooth extraction. The main question it aims to answer is:
Does laser therapy improve wound healing and bone regeneration after tooth extraction?
Researchers will compare a laser to sham laser therapy to see if the laser enhances wound healing and bone regeneration.
Participants will:
Have exposure to laser or sham laser therapy immediately after tooth extraction Record their pain intensity on days 2, 4, 6 and 14 Visit the clinic after 10 days for follow-up Again, visit the clinic after 4 months for evaluation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 21 years old, regardless of gender
- •Non-traumatic tooth extraction of the lower jaw is indicated
- •Willing for dental implant surgery
- •Dental appointments are available at the study place
- •Absence of active infection at the extraction site
- •Signed informed permission is provided.
排除标准
- •Pregnant, lactating, and menopausal women
- •Those having head and neck radiotherapy
- •Those with any sort of acute infection (e.g., periodontal abscess), immune deficiency, or metabolic conditions such as diabetes mellitus and osteoporosis
- •Patients will also be eliminated if they have a complication during surgery, such as bleeding or operational difficulties, or if the procedure takes longer than 90 minutes.
结局指标
主要结局
Wound healing will be assessed in both the experimental and control groups.
时间窗: 1 year
Wound healing will be assessed using the Landry, Turnbull, and Howley index after 7 days, and a score will be given ranging from 1 to 5, where 1 indicates very poor healing, and 5 indicates excellent healing. (score range: 1-very poor, 2-poor, 3-good, 4-very good, 5-excellent)
Bone regeneration will be assessed in both the experimental and control groups.
时间窗: 1 year
A postoperative cone beam computed tomography (CBCT) will be taken immediately after extraction, followed by a CBCT 4 months after extraction. The immediate CBCT will be done to study the density of healthy bone in the apical region of the extracted tooth socket. This value will serve as the baseline for further assessment. The density obtained will then be compared with the bone formed at the end of 4 months in the extraction socket with and without laser therapy. Taking mean readings in the grayscale measurements from the periapical region will allow for the calculation of bone density.
次要结局
- Pain intensity will be measured in both the experimental and control groups.(1 year)
研究者
Amna Nauman
Professor
Sharif Medical Research Center