A Randomized clinical study to evaluate the efficacy of Tryushanadi Sattu and Mustadi Apatarpan Kwatha in management of Sthaulya w.s.r.to Obesity
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- There is reduction in weight and bmi and anthropometry I.e. objective criteria and too the sign and symptoms of sthaulya (obesity)
研究概览
简要总结
In modern era of globaliization, India is currently witnessing rising number of people who are obese .Many among the Indian population have started relying on processed food that contain a huge percentage of trans-fat, sugar and other unhealthy and artificial ingredients. Sthaulya is one such lifestyle disorders Sedentary lifestyles are leading people to silent self-destruction, making one in every five Indian men and women obese. It has reached epidemic properties globally. 39% of adults in the world are overweight.
Sthaulya is included under eight undesirable conditions (Ashtau Nindita), Shleshm Nanatmaj, Samtarpana Nimittaja Atinindita,Ati Brihmana Nimitaja and Bahu Dosha Janita Vikara. Moreover, Sushruta has emphasized on metabolic disturbances (Dhatvagnimandya) in the etiopathogenesis of Sthaulya. The patient of Sthaulya exhibits very strange phenomenon. Their appetite is excessive and whatever they eat is quickly digested, which indicates hyperfunctioning of the Jatharaagni. Besides this, the patient suffers from laziness, may be due to under supply of energy, which may be due to hypofunctioning of Bhutaagni. Further Dhatvagni also seems to be disturbed, as in Sthaulya patient mainly Medo-Dhatu is formed and there is deficiency of other Dhatu.Hence, it can be inferred that in Sthaulya, Jatharagni is Tikshna, Bhutagni is Manda and Dhatvagni is disturbed in their respective functions. On the basis of the above-mentioned facts of pathogenesis of Sthaulya, it can be said that the drug, which decreases Jatharagni particularly Abhyavahrana Shakti, increases Bhutagni and corrects the functions of Dhatvagni and at the same time have Medo-hara, Kapha-hara and Vatahara actions, may be suitable for its management.
Therefore Today it is need to find the drug which is cost effective, easily available everywhere and easy to follow one such preparation is Tryushanadi sattu mention in charak samhita having properties like kaphagna, medohara. Probable mode of action in Sthaulya is caused by excessive use or practice of Kapha Vardhaka Ahara and Vihara mentioned as Santarpaka Nidana like, Ati-Guru, Ati-Snigdha, Ati-Pichchhil, Atishita, Navanna-pana, Ati-nidra, Ati-aasana, Avyayama etc. These Nidanas vitiate Rasa Dhatvagni, Meda Dhatvagni, Kapha Dosha and Vata Dosha. Trikatu Churna has Ushna, Laghu, Ruksha Guna and Deepana, Kapha-vata Hara and Shaulyahara Karma expected to increase the power of Rasa and Meda Dhatvagni, decrease in Kapha and Vata and thus decrease in further formation of Aaama Meda Dhatu and its deposition in body results in an improvement in Sthaulya.
Hence this topic is been selected
The study is divided into two arm interventional with Tryushanadi sattu and Mustadi Apatarpan kwatha .
Randomizationis done by using computer software.
35 patients of each interventional and comparator selected.
patients with signed consent are going to evaluate efficacy of Tryushanadi sattu and Mustadi Apatarpan Kwatha in management of sthaulya (Obesity)
Acceessment will be done on the basis of Subjesctive and Objective Parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient having sign and symptoms of sthaulya Kshudra Shwas, Kshudhatimatra, Pipasadhikya, Swedadhikya, Atinidra,Daurgandhya, Daurbalya.
- •Patient between age group 20-50 yrs, irrespective of gender c.Patients with BMI More than 25 but less than 39.
排除标准
- •Patients is known case of cardiac, pulmonary renal and hepatic diseases, etc.
- •Patients having medical emergencies associated with like Coronary Heart disease, Atherosclerosis, Myocardial infarction etc.
- •Pregnant females and lactating women’s.
- •Patients having history of diabetic mellitus, thyroid disorder and HTN, and other endocrine disease.
- •Overweight due to drug eg.
- •corticosteroids.
- •Patients is suffering from peptic ulcer disorder, bledding disorder were excluded.
结局指标
主要结局
There is reduction in weight and bmi and anthropometry I.e. objective criteria and too the sign and symptoms of sthaulya (obesity)
时间窗: 6 weeks
次要结局
- 1. To study the effect of Tryshanadi saktu in the signs and symptoms of sthaulya like kshudhadhikya(Nidradhikya,Swedadhikya, Daurbalya, Trushnadhikya etc. before and after treatment.)
研究者
Mahesh Ashokrao Patil
R A Podar Medical (Ayu) College Worli,Mumbaii