The role of the intervertebral disc in the progression of adolescent idiopathic scoliosis: a prospective study using magnetic resonance imaging.

Recruiting

• Conditions: Scoliosis; three-dimensional deviation of the spinal axis; 10005959

• Registration Number: NL-OMON50461
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Patients diagnosed with adolescent idiopathic scoliosis
- Presence of right convex main thoracic structural curve, either in Lenke type
1 or 2;
- Female gender
- Between 10-16 years of age
- Cobb*s angle 20-40 degrees

Exclusion Criteria

- Skeletal maturity
- Presence of any additional spine pathology such as spondylolysis or
-listhesis, M. Scheuermann, congenital spinal abnormalities, spinal tumors and
spinal trauma
- Previous spinal surgery
- Neurological symptoms, deficits or pathology
- Syndromes associated with disorders of growth
- Any contra-indication for MR Imaging

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Each MR scan will consist of a standard sagittal-only T2W, developed for IVD<br /><br>imaging. The IVDs of the spine between T1 and S1 will be scanned. The different<br /><br>parameters will be measured semi-automatically.<br /><br><br /><br>The primary study parameters are changes in MRI timing, sensitivity, dynamic<br /><br>range, spatial distribution and morphological changes of the IVD during AIS<br /><br>progression.<br /><br><br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameters are:<br /><br>1. Correlation of the findings on MR-imaging with patient-reported outcome<br /><br>measurements using the SRS-22 questionnaire</p><br>