Microbiota Community of Irritable Bowel Syndrome in Episodes and Remission Phase

• Conditions: Irritable Bowel Syndrome
• Interventions: Other: collect faeces from participants

• Registration Number: NCT02566629
• Lead Sponsor: Shandong University

Brief Summary

Analyze microbiota community of irritable bowel syndrome in episodes phase and remission phase.

Detailed Description

The pathophysiology of IBS is incompletely understood, it may involve an altered intestinal microbiota. Since the microflora composition of IBS is various in different studies, The investigators plan to compare the intestinal microbiota of IBS patients in episodes phase and remission phase with healthy controls,trying to find the difference.

Study Timeline

• Study Start: 2015-07
• Status Verified: 2015-09
• Study First Submitted: 2015-09-30
• Study First Submitted QC: 2015-10-01
• Last Update Submitted: 2015-10-01
• Study First Posted: 2015-10-02
• Last Update Posted: 2015-10-02
• Primary Completion: 2015-11
• Study Completion: 2015-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• the presence of Rome III criteria for IBS ;
• Patients scheduled for colonoscopy examination or having negative screening examinations
• Aged between 18 and 65 years old

Exclusion Criteria

• Antibiotic, probiotic or laxative usage within 4 weeks.
• organic gastrointestinal diseases
• Severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc.
• pregnancy or lactation.
• previous major or complicated abdominal surgery.
• severe endometriosis and dementia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy controls	collect faeces from participants	collect faeces from healthy controls
IBS patients in episodes phase	collect faeces from participants	collect faeces from IBS patients in episodes remission phase
IBS patients in remission phase	collect faeces from participants	collect faeces from IBS patients in remission phase

Primary Outcome Measures

Name	Time	Method
microbiota community among IBS patients in episodes phase,remission phase and healthy controls	5 months

Secondary Outcome Measures

Name	Time	Method
quality of life in IBS patients	5 months

Trial Locations

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University; 🇨🇳 Jinan, Shandong, China