NCT00299143已完成不适用
Pilot Study on Shear-induced Platelet Aggregation in Acute Coronary Syndromes
Institut National de la Santé Et de la Recherche Médicale, France2 个研究点 分布在 1 个国家目标入组 97 人开始时间: 2005年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 试验地点
- 2
- 主要终点
- Measurement of platelet aggregation induced by shear rates
研究概览
简要总结
The purpose of this study is to determine whether shear-induced platelet aggregation is able to discriminate first acute coronary syndrome (ACS) from recurrent ACS
详细描述
Predictive factors of recurrence of ACS are not well determined. Platelet aggregation and leucocyte activation seem to be involved in the pathogenesis. The aim of our study is to compare SIPA, platelet activation and platelet-leucocytes aggregates on the onset of the ACS and 3 months later in 2 groups of patients scheduled for a first episode of ACS or recurrent ACS .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •over 18 years old. informed consent signed. acute coronary syndrome not associated with co-morbidity as bleeding diathesis or myocardial infarction during the procedure.
- •clinical symptoms in agreement with myocardial infarction during the preceding 24 hours.
- •CK OR troponin elevation and one or more of the following criteria: ECG modifications transient ST elevation>1 mm. new inversion of ST <1 mm on 2 contiguous derivations.
排除标准
- •Acute coronary syndrome with persistent ST elevation. Angioplasty in emergency before blood sampling. Inflammatory disease or cancer. Coagulation abnormalities. Antiphospholipid syndrome. Treatment by vitamin K antagonist. Severe disease with life expectancy lower than 2 years. One-year follow up impossible.
结局指标
主要结局
Measurement of platelet aggregation induced by shear rates
时间窗: Day 1, Month 3
Using rotational viscometer
次要结局
- Measurement of platelet aggregation induced by ADP (Adenosine 5'-diphosphate)(Day 1, Month 3)
- Measurement of P-selectin membrane density(Day 1, Month 3)
- Measurement of activated alphaIlbbeta3 membrane density(Day 1, Month 3)
- Determination of the number of platelet-leucocyte aggregates in the circulating blood(Day 1, Month 3)
- Measuring Von Willebrand factor(Day 1, Month 3)
研究者
Nadine Ajzenberg
professor
Institut National de la Santé Et de la Recherche Médicale, France
研究点 (2)
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