REmission MEchanisms in Depressio

Not Applicable

Completed

• Conditions: Topic: Mental Health Research Network, Primary Care Research Network for England; Subtopic: Depression, Not Assigned; Disease: Depression, All Diseases; Mental and Behavioural Disorders; Depressive episode

• Registration Number: ISRCTN89615545
• Lead Sponsor: niversity of Manchester (UK)

Brief Summary

Published conference abstracts: 2009 results in: https://doi.org/10.1016/S0924-977X(09)70565-6 (added 26/11/2019) 2009 results in: https://doi.org/10.1016/S0924-977X(09)70594-2 (added 26/11/2019) 2009 results in: Arnone D, Pegg EJ, McKie S, Downey D, Elliott R, Williams SR, Deakin JFW, Anderson IM (2009) Current major depression but not remitted major depression shows increased neural responses to sad facial expressions. Journal of Psychopharmacology Suppl to Vol 23(6), A26 (added 26/11/2019) 2009 results in: Pegg EJ, Arnone D, McKie S, Elliott R, Deakin JFW, Anderson IM (2009) Citalopram treatment increases neural responses to positive words and decreases responses to negative words in depression. Journal of Psychopharmacology Suppl to Vol 23(6), A25 (added 26/11/2019) Refereed papers: 2012 results in: https://www.ncbi.nlm.nih.gov/pubmed/22854930 (added 26/11/2019) 2013 results in: https://www.ncbi.nlm.nih.gov/pubmed/23128153 (added 26/11/2019) 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/30877271 (added 26/11/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-04-29
• Study Completion: 2010-05-31
• Last Update Posted: 6 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

Depressed subjects:
1. DSM-IV major depressive episode with a Montgomery Asberg Depression Rating Scale (MADRS) score greater than 20
2. Psychotropic drug-free for greater than 2 weeks (2 months for fluoxetine)

Controls:
3. Psychiatrically well

All:
4. Good physical health
5. Aged 18 - 55 years, either sex

Exclusion Criteria

Depressed subjects:
1. Duration of depressive episode greater than 1 year or depression superimposed on dysthymia
2. Failure to respond to 2 antidepressants given for 6 weeks at an adequate dose in current episode
3. Failure to respond to citalopram or escitalopram in current episode
4. Allergy or intolerance to citalopram or escitalopram
5. Contraindications to selective serotonin reuptake inhibitor (SSRI) treatment (e.g., history of peptic ulcer/gasterointestinal [GI] bleeding or taking non-steroidal anti-inflammatory drugs [NSAIDs], in the absence of concurrent ulcer-protective treatment)
6. Other concurrent psychotropic medication except for small stable doses of short acting hypnotics
7. Electroconvulsive therapy (ECT) or lithium in current episode
8. Significant suicidal risk or likely need for other psychiatric intervention during the study period
9. Other current co-morbid Axis I psychiatric disorders except anxiety disorders (excluding OCD) secondary to depression
10. Primary cluster A or B Axis II (personality) disorder
11. History of psychotic, bipolar or organic psychiatric disorder

Controls:
12. Personal psychiatric history including Axis II (personality) disorder
13. Significant family psychiatric history (eg psychosis, recurrent affective disorder)
14. Psychotropic medication

All:
15. Medical condition that might compromise subject safety or interfere with interpretation of results
16. History of significant head trauma (loss of consciousness greater than 5 minutes)
17. Current medication for a medical condition that would compromise subject safety or interfere with interpretation of results in the judgement of the investigator (e.g., possible exceptions intermittent analgesics, contraceptive pill, occasional inhaler for mild asthma)
18. Subjects whose English is insufficiently good to enable them to validly complete the questionnaires or perform simple computer-based tasks
19. Pregnancy or no effective contraception in women of childbearing age
20. Any illicit drug use in the last 2 months and a lifetime history of a DSM-IV substance or alcohol misuse disorder
21. Current Alcohol use above 14 units/week for women and 21 units/week for men
22. Excessive caffeine use (greater than 6 cups of coffee/day)
23. Smoking greater than 10 cigarettes/day
24. Contraindications to scanning (determined by standard screening instrument)
25. Likely not to be able to complete the full study for any reason

Study & Design

• Study Type: Interventional
• Study Design: Not specified