REmission MEchanisms in Depression
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Manchester (UK)
- Enrollment
- 72
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Published conference abstracts: 2009 results in: https://doi.org/10.1016/S0924-977X(09)70565-6 (added 26/11/2019) 2009 results in: https://doi.org/10.1016/S0924-977X(09)70594-2 (added 26/11/2019) 2009 results in: Arnone D, Pegg EJ, McKie S, Downey D, Elliott R, Williams SR, Deakin JFW, Anderson IM (2009) Current major depression but not remitted major depression shows increased neural responses to sad facial expressions. Journal of Psychopharmacology Suppl to Vol 23(6), A26 (added 26/11/2019) 2009 results in: Pegg EJ, Arnone D, McKie S, Elliott R, Deakin JFW, Anderson IM (2009) Citalopram treatment increases neural responses to positive words and decreases responses to negative words in depression. Journal of Psychopharmacology Suppl to Vol 23(6), A25 (added 26/11/2019) Refereed papers: 2012 results in: https://www.ncbi.nlm.nih.gov/pubmed/22854930 (added 26/11/2019) 2013 results in: https://www.ncbi.nlm.nih.gov/pubmed/23128153 (added 26/11/2019) 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/30877271 (added 26/11/2019)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Depressed subjects:
- •1\. DSM\-IV major depressive episode with a Montgomery Asberg Depression Rating Scale (MADRS) score greater than 20
- •2\. Psychotropic drug\-free for greater than 2 weeks (2 months for fluoxetine)
- •3\. Psychiatrically well
- •4\. Good physical health
- •5\. Aged 18 \- 55 years, either sex
Exclusion Criteria
- •Depressed subjects:
- •1\. Duration of depressive episode greater than 1 year or depression superimposed on dysthymia
- •2\. Failure to respond to 2 antidepressants given for 6 weeks at an adequate dose in current episode
- •3\. Failure to respond to citalopram or escitalopram in current episode
- •4\. Allergy or intolerance to citalopram or escitalopram
- •5\. Contraindications to selective serotonin reuptake inhibitor (SSRI) treatment (e.g., history of peptic ulcer/gasterointestinal \[GI] bleeding or taking non\-steroidal anti\-inflammatory drugs \[NSAIDs], in the absence of concurrent ulcer\-protective treatment)
- •6\. Other concurrent psychotropic medication except for small stable doses of short acting hypnotics
- •7\. Electroconvulsive therapy (ECT) or lithium in current episode
- •8\. Significant suicidal risk or likely need for other psychiatric intervention during the study period
- •9\. Other current co\-morbid Axis I psychiatric disorders except anxiety disorders (excluding OCD) secondary to depression
Outcomes
Primary Outcomes
Not specified