Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosus (DLE) and in healthy controls.
研究概览
简要总结
The purpose of this research study is to see if a specific protein that we are interested in is involved in scarring hair loss. If these proteins are involved, further genetic work may also better define the disease as well as future treatment options.
详细描述
This is a single-center study, designed to evaluate the expression of Fas protein in skin biopsies of patients with scarring alopecia including fourteen patients with central centrifugal scarring alopecia (CCSA), three patients with lichen planopilaris (LP) and three patients with discoid lupus erythematosus (DLE). Skin biopsies of five healthy participants will be used as controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Participants ages 30 years or older with a biopsy- proven diagnosis of CCSA.
- •Undergone standard of care treatment for CCSA by a WFUSM Dermatologist
- •Women of child bearing age will be required to have a negative pregnancy test in order to participate in the study
- •Participants ages 30 years or older with a biopsy- proven diagnosis of LP.
- •Participants ages 30 years or older with a biopsy- proven diagnosis of DLE.
- •Healthy participants must be ages 30 years or older.
排除标准
- •Age less than 30 years of age.
- •Clinically evident bacterial or viral infection of the scalp.
- •Pregnant or nursing woman of child-bearing potential.
- •Participation in any other investigative research study involving study medication.
- •Inability to return for the biopsy visit.
结局指标
主要结局
To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosus (DLE) and in healthy controls.
时间窗: 8 weeks
次要结局
- To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia before and after treatment with intralesional and topical steroids.(8 weeks)