French Biological Observatory on Lung Cancer in Never Smokers
- Conditions
- Lung Cancer
- Registration Number
- NCT01465854
- Lead Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
- Brief Summary
Lung cancer in non-smokers (LCINS) is an increasing public health problem. The BioCAST (IFCT-1002) study, promoted by Intergroupe Francophone de Canc茅rologie Thoracique (IFCT), focuses on this entity. It is a national, multicentric, prospective epidemiological study. Main objective is to describe the clinical and molecular epidemiology of LCINS in a large French cohort composed by cases newly diagnosed in participating centres (around to 1000 patients expected). The clinical component of the study is based on collecting data directly from the patient through a standardized questionnaire during a telephone interview with a health professional. The biologic component includes a blood sample collection. A large genomic-wide association study and an epigenetic study are also planned. BioCAST hopes to provide concrete answers to clinicians and patients questions about this new and frequent entity.
- Detailed Description
According to WHO, 25% of lung cancer worldwide occurs in lifelong never smokers. Lung cancer in never smokers (LCINS) shows many clinical, epidemiological, molecular and genomic differences comparing to tobacco-related neoplasm. So, it is now considered as a separate entity. LCINS particularly occurs in women and Asian. They are mainly adenocarcinoma. Known risk factors are occupational exposure, environmental tobacco smoking, familial history of cancer, personal medical history of lung disease or environmental causes. LCINS carries more frequently molecular abnormalities leading to efficacy of targeted therapies (EGFR mutation, EML4-ALK inversion, less frequent mutations of KRAS ...). However, most data come from retrospectives studies, subgroups analysis and/or from Asian cohort even though it is a disease with a significant geographic variability. Finally, few studies focus on correlations between risk factors and molecular or genomic abnormalities.
For these reasons and considering that LCINS is an increasing public health problem, IFCT (Intergroupe Francophone de Canc茅rologie Thoracique) states to promote the BioCAST study (IFCT-1002). It is a national, multicentric, prospective epidemiological study. Main objective is to describe the clinical and molecular epidemiology of LCINS in a French population composed by all cases newly diagnosed in participating centres (500 to 1500 patients expected). BioCAST include a clinical and a biological part. The clinical component is based on collecting data directly from the patient through a standardized questionnaire during a telephone interview with a health professional. The biologic component includes a blood sample collection. A large genomic wide association study and an epigenetic study (including micro RNA study) are also planned. Other objectives are looking for correlations between clinical factors and molecular abnormalities; and looking for new oncogene in this specific population.
BioCAST hopes to provide concrete answers to clinicians and patients about this new and frequent entity.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 422
- never smokers (i.e. who has smoked less than 100 cigarettes per lifetime)
- at least 18 years of age
- newly diagnosed lung cancer
- patient having access to a telephone
- french-speaking patient or patient who could be easily helped in his mother tongue during a phone interview
- signed informed consent
- smokers
- chemotherapy already initiated at enrollment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence of EGFR mutations in never smokers with newly diagnosed non-small-cell lung cancer (NSCLC) November 2011 to January 2013
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (82)
Centre Hospitalier du Pays d'Aix
馃嚝馃嚪Aix-en-Provence, France
CHD Castelluccio
馃嚝馃嚪Ajaccio, France
CH Annonay
馃嚝馃嚪Annonay, France
Centre Fran莽ois Baclesse
馃嚝馃嚪Caen, France
CHI Annemasse-Bonneville
馃嚝馃嚪Annemasse, France
CH Jacques-C艙ur - Pneumologie
馃嚝馃嚪Bourges, France
CH Chambery
馃嚝馃嚪Chambery, France
CH de Chartres H么pital Louis Pasteur
馃嚝馃嚪Chartres, France
H么pital Priv茅 d'Antony
馃嚝馃嚪Antony, France
CH de la C么te Basque
馃嚝馃嚪Bayonne, France
CHU Besan莽on
馃嚝馃嚪Besan莽on, France
H么pital Fleyriat
馃嚝馃嚪Bourg en Bresse, France
H么pital Ambroise Par茅 - Pneumologie
馃嚝馃嚪Boulogne, France
CH Cahors
馃嚝馃嚪Cahors, France
CH de Chauny
馃嚝馃嚪Chauny, France
H么pital de Cholet - Pneumologie
馃嚝馃嚪Cholet, France
HCL H么pital Louis Pradel
馃嚝馃嚪Bron, France
CH de Cannes
馃嚝馃嚪Cannes, France
Centre M茅dical Nicolas de Pontoux
馃嚝馃嚪Ch芒lon-sur-Sa么ne, France
H么pital Pasteur
馃嚝馃嚪Colmar, France
CH de Ch芒lons-en-Champagne
馃嚝馃嚪Ch芒lons-en-Champagne, France
HIA Percy - Pneumologie
馃嚝馃嚪Clamart, France
CH Compi猫gne - Pneumologie
馃嚝馃嚪Compi猫gne, France
CHRU Grenoble
馃嚝馃嚪Grenoble, France
CH R茅gion Saint-Omer
馃嚝馃嚪Helfaut, France
CH Lagny-sur-Marne
馃嚝馃嚪Lagny-sur-Marne, France
CH de Versailles
馃嚝馃嚪Le Chesnay, France
CH du Mans
馃嚝馃嚪Le Mans, France
Centre Oscar Lambret
馃嚝馃嚪Lille, France
H么pital Calmette
馃嚝馃嚪Lille, France
CH de Longjumeau
馃嚝馃嚪Longjumeau, France
CH Lyon Sud - Pneumologie
馃嚝馃嚪Lyon, France
CH de Macon
馃嚝馃嚪Macon, France
CH Saint Joseph Saint Luc
馃嚝馃嚪Lyon, France
Clinique Mutualiste Eug猫ne Andr茅
馃嚝馃嚪Lyon, France
HIA Desgenettes
馃嚝馃嚪Lyon, France
Polyclinique du Parc
馃嚝馃嚪Maubeuge, France
H么pital La毛nnec - CHU de Nantes
馃嚝馃嚪Nantes, France
H么pital de la Croix Rousse
馃嚝馃嚪Lyon, France
H么pital Ambroise Par茅
馃嚝馃嚪Marseille, France
H么pital Nord - Oncologie Multidisciplinaire & Innovations Th茅rapeutiques
馃嚝馃嚪Marseille, France
CHR Metz Thionville
馃嚝馃嚪Metz, France
CH Mont茅limar
馃嚝馃嚪Mont茅limar, France
CH Nevers
馃嚝馃嚪Nevers, France
CH de Mont-De-Marsan
馃嚝馃嚪Mont-De-Marsan, France
CH de Mulhouse
馃嚝馃嚪Mulhouse, France
CHU Nancy
馃嚝馃嚪Nancy, France
CHR d'Orl茅ans La Source
馃嚝馃嚪Orl茅ans, France
GH Paris Saint-Joseph
馃嚝馃嚪Paris, France
H么pital Bichat - Claude - Bernard
馃嚝馃嚪Paris, France
H么pital Saint Antoine
馃嚝馃嚪Paris, France
CH de Rambouillet
馃嚝馃嚪Rambouillet, France
Institut Jean Godinot
馃嚝馃嚪Reims, France
CHU Charles Nicolle
馃嚝馃嚪Rouen, France
Institut de Canc茅rologie de la Loire
馃嚝馃嚪Saint Priest en Jarez, France
CH de Saint-Brieuc
馃嚝馃嚪Saint-Brieuc, France
CHU Strasbourg
馃嚝馃嚪Strasbourg, France
H么pital Foch
馃嚝馃嚪Suresnes, France
H么pital Font-Pr茅 - Pneumologie
馃嚝馃嚪Toulon, France
CHI de la Haute-Sa么ne - Pneumologie
馃嚝馃嚪Vesoul, France
Clinique Mutualiste Les Portes du Sud
馃嚝馃嚪V茅nissieux, France
CH de Villefranche - Pneumologie
馃嚝馃嚪Villefranche, France
CHU d'Angers
馃嚝馃嚪Angers, France
CHU C么te de N芒cre
馃嚝馃嚪Caen, France
Clinique Claude Bernard
馃嚝馃嚪Albi, France
CHIC
馃嚝馃嚪Aulnay-Sous-Bois, France
CH Pierre Oudot
馃嚝馃嚪Bourgoin-Jallieu, France
H么pitral Gabriel Montpied - Pneumologie
馃嚝馃嚪Clermont-Ferrand, France
CHI Cr茅teil
馃嚝馃嚪Cr茅teil, France
CH de Dax
馃嚝馃嚪Dax, France
Cabinet priv茅
馃嚝馃嚪Dijon, France
Centre d'Oncologie du Parc
馃嚝馃嚪Dijon, France
Centre Georges Fran莽ois Leclerc
馃嚝馃嚪Dijon, France
CHU H么pital du Bocage
馃嚝馃嚪Dijon, France
Centre Antoine Lacassagne
馃嚝馃嚪Nice, France
H么pitaux du L茅man - Pneumologie et Maladies Infectieuses
馃嚝馃嚪Thonon-les-Bains, France
CHU Tours - Pneumologie
馃嚝馃嚪Tours, France
CH Valence
馃嚝馃嚪Valence, France
Clinique Pasteur
馃嚝馃嚪Toulouse, France
Clinique Saint Jean du Languedoc
馃嚝馃嚪Toulouse, France
H么pital Larrey - Pneumologie
馃嚝馃嚪Toulouse, France
H么pital Tenon
馃嚝馃嚪Paris, France