Investigating the mechanisms of muscle fatigue and cognitive symptoms in subclinical hypothyroidism

ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)0 个研究点目标入组 30 人开始时间: 2013年5月15日最近更新: 2019年3月18日

适应症

试验速览

暂无简介。

•1. Aged 18 to 65 years
•2. Subjects with confirmed SCH thyroid stimulating hormone (TSH) between 4.1 and 10.0 for more than 3 months
•3. Fatigue Impact Score greater than 40

•1. Subjects with previous thyroid disease or on thyroid hormone replacement, anti-thyroid drugs, oral contraceptive pill (OCP), hypotensive agents, aspirin, statins or angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blocker
•2. Subjects with known diabetes mellitus/impaired glucose tolerance (IGT)/impaired fasting glucose (IFG)
•3. Known renal failure or a serum creatinine greater than 120 µmol/l within the past 3 months
•4. Previous participation in a clinical trial within the past month
•5. Previous history of vascular/heart disease
•6. Malignancy (any)
•7. Active infections
•8. Body mass index (BMI) greater than 35
•9. Psychiatric disease
•10. Drug abuse
•11. Previous major head injuries/epilepsy
•12. Pacemakers/cerebral aneurysm clips
•13. Pregnancy

发起方

ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)