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Clinical Trials/ISRCTN70749570
ISRCTN70749570
Completed
未知

Investigating the mechanisms of muscle fatigue and cognitive symptoms in subclinical hypothyroidism

ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)0 sites30 target enrollmentMay 15, 2013
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ConditionsSubclinical hypothyroidismNutritional, Metabolic, EndocrineSubclinical iodine-deficiency hypothyroidism

Overview

Phase
未知
Intervention
Not specified
Conditions
Subclinical hypothyroidism
Sponsor
ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Enrollment
30
Status
Completed
Last Updated
7 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
May 15, 2013
End Date
January 10, 2012
Last Updated
7 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Aged 18 to 65 years
  • •2\. Subjects with confirmed SCH thyroid stimulating hormone (TSH) between 4\.1 and 10\.0 for more than 3 months
  • •3\. Fatigue Impact Score greater than 40

Exclusion Criteria

  • •1\. Subjects with previous thyroid disease or on thyroid hormone replacement, anti\-thyroid drugs, oral contraceptive pill (OCP), hypotensive agents, aspirin, statins or angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blocker
  • •2\. Subjects with known diabetes mellitus/impaired glucose tolerance (IGT)/impaired fasting glucose (IFG)
  • •3\. Known renal failure or a serum creatinine greater than 120 µmol/l within the past 3 months
  • •4\. Previous participation in a clinical trial within the past month
  • •5\. Previous history of vascular/heart disease
  • •6\. Malignancy (any)
  • •7\. Active infections
  • •8\. Body mass index (BMI) greater than 35
  • •9\. Psychiatric disease
  • •10\. Drug abuse

Outcomes

Primary Outcomes

Not specified

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