Investigating the Molecular Mechanisms Underpinning Glucose Stimulated Release of Stored Enteral Lipid in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Blood lipid responses to glucose drink
研究概览
简要总结
During dietary fat absorption, the gut packages the majority of the fats into lipid particles that are secreted into blood circulation. The gut is also capable of storing a considerable amount of fats that can be released at a later time upon receiving certain stimulus signals. One of the signals is glucose ingestion. This protocol examines blood lipid responses to a glucose drink. Participants drink a fatty formula and 5 hours later drink either a glucose solution or water (as control), in one of two randomized study visits. Blood lipid levels are monitored throughout the study period.
详细描述
Participants are recruited after obtaining informed consent. They first have a high fat liquid formula. 5 hours later, they drink 50 grams of glucose in 50 ml of water in one visit and 50 ml of water in another. The 2 visits are randomized. Blood samples are taken before and after they drink the high fat liquid formula, and continued until 3 hours after they drink glucose or water. Lipid levels in the blood samples are measured in the lab.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women, aged 18 to 60 years requiring endoscopy and duodenal biopsies for clinical indications, with no contraindications to the procedure, as judged by Dr. Bookman.
- •Body mass index 20 to 27 kg/m2
排除标准
- •Patients with active inflammatory bowel disease
- •Patients with Celiac disease, exocrine pancreatic insufficiency or small bowel malabsorption
- •Patients with active bowel malignancy
- •Patients with diabetes mellitus or known/ suspected motility disorders of the gut
- •Patients with decompensated liver disease
- •Patients on ezetemibe or bile acid sequestrants
- •Unstable cardiac or respiratory disease
- •Any changes to medication in the preceding month.
研究组 & 干预措施
Glucose
50 grams of glucose in 50 ml water
干预措施: Glucose (Dietary Supplement)
Water
50 ml water
干预措施: Water (Dietary Supplement)
结局指标
主要结局
Blood lipid responses to glucose drink
时间窗: 8 hours
Blood lipid levels are measured after drinking a glucose solution
次要结局
未报告次要终点