Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation on Lower Limb Motor Function

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Other: Constrained induced movement; Other: Proprioceptive Neuromuscular facilitation

• Registration Number: NCT05191524
• Lead Sponsor: Riphah International University

Brief Summary

Stroke, described as a neurological deficit caused by the interruption of cerebral blood flow, is one of the leading causes of mortality and morbidity throughout the world. It is the second most common medical condition and the major cause of disability in adults. Recovery following stroke revolves around the severity of sensory, motor, and cognitive impairments. Lower extremity impairment is one of the major post-stroke conditions which can cause difficulty in performing activities of daily living, gait abnormalities, increased risk of fall, and restriction in social participation. Rehabilitation after stroke is the primary mechanism through which it can achieve functional recovery and independence, which is based on the principles of motor learning and neuroplasticity.

Detailed Description

There have been many rehabilitation techniques to treat post-stroke impairments. These include aerobic exercises, the Bobath approach, proprioceptive neuromuscular facilitation (PNF) constraint-induced movement therapy (CIMT), and mobilization and stimulation of neuromuscular tissue. The selection of techniques at the defined level of recovery varies among clinicians.

Constraint-induced movement therapy (CIMT) is a neurological rehabilitation technique that has been used in various neurological disorders including stroke both in acute and chronic stages, traumatic brain injury, cerebral palsy, multiple sclerosis, and spinal cord injury to improve motor function and strengthen weak muscles which are characterized by the restraint of the less affected extremity accompanied by the shaping and repetitive task-oriented training of more affected extremity.

Proprioceptive facilitation (PNF) is one of the major therapeutic techniques aimed at enhancing the essential characteristics required for the functional ambulation of patients with hemiplegia, such as muscular control, strength, and flexibility. Changes in the excitation of the cortical motor area mediate this and the corresponding.

Motor neurons. Previous researches are on the separate effect of CIMT and they have conducted PNF approaches, but there is no study available on the comparison of the effect of both techniques on lower limb function in stroke patients. Most of the studies administered PNF in combination with other approaches and the duration of intervention in these studies was in favor of CIMT groups compared to PNF. Therefore, this study is aimed at determining the comparative effect of CIMT and PNF on lower limb recovery.

Study Timeline

• Study First Submitted: 2021-12-29
• Study First Submitted QC: 2021-12-29
• Study First Posted: 2022-01-13
• Study Start: 2022-01-15
• Primary Completion: 2022-06-27
• Study Completion: 2022-06-27
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-17
• Last Update Posted: 2022-09-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Both male and female
• Patients who will be diagnosed with hemiplegia due to stroke
• Patient who has an asymmetrical stance, ability to walk and stand with minimal assistance
• Patient must have 15 degrees of knee flexion in the affected limb
• Mini mental state examination Mini Mental State Examination >23

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Exclusion Criteria

• Patients who cannot perform the active movement of a limb due to pre stroke musculoskeletal problems
• Cardiopulmonary diseases which could hinder their ability to take part in rehabilitation
• Patient with impaired cognition

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Constrained induced movement therapy	Constrained induced movement	In this group of patients, they will use the CIMT technique for treatment. Patient will perform following tasks, while unaffected limb in constrains for 3 hours/day * Sit-to-Stand * Forward and Backward stepping * Stair Climbing and Descending (only the first stair will be used) * Side-to-Side stepping with the affected limb
Proprioceptive Neuromuscular facilitation therapy	Proprioceptive Neuromuscular facilitation	Different PNF components (such as commands, stretching, timing, and manual resistance) will be used for optimizing patients' output. We will do ten repetitions of each pattern before Proceeding to the next pattern. The PNF patterns in the set used in the study will be : Lower extremity: \< Flexion-abduction-external rotation (knee flexed and knee extended) \< Extension-adduction-internal rotation (knee flexed and knee extended) \< Flexion-adduction-internal rotation (knee flexed and knee extended) \< Extension-abduction-external rotation (knee flexed and knee extended

Primary Outcome Measures

Name	Time	Method
Fugl-Meyer Assessment (FMA)	week 6	The FMA scale is a 226-point multi-item Likert-type scale developed as an evaluative measure of recovery from hemiplegic stroke. They divided it into 5 domains: motor function, sensory function, balance, joint range of motion, and joint pain. Each domain contains multiple items, each scored on a 3-point ordinal scale (0 = cannot perform, 1 = performs partially, 2 = performs fully).
Timed up and go test	week 6	The Timed Up and Go (TUG) is a screening tool used to test basic mobility skills of frail elderly patients (60-90 years old). They can use the TUG with but is not limited to, persons with stroke.; 10s Completely independent With or without walking aid for ambulation and transfers; \< 20s Independent for main transfers With or without walking aid, independent for basic tub or shower transfers and able to climb most stairs and go outside alone; \> 30s Requires assistance dependent in most activities
Berg Balance Scale	week 6	The Berg balance scale is used to objectively determine a patient's ability (or inability) to safely balance during a series of predetermined tasks. It is a 14 item list with each item comprising a five-point ordinal scale ranging from 0 to 4, with 0 showing the lowest level of function and 4 the highest level of function and takes approximately 20 minutes to complete.

Trial Locations

Locations (1)

Helping Hand institute of Rehabilitation Sciences; 🇵🇰 Mansehra, Pakistan