Rescue Extracranial Vertebral Stenting in Tandem Occlusions

Not Applicable

Completed

• Conditions: Acute Stroke; Ischemic Stroke, Acute; Vertebro Basilar Ischemia
• Interventions: Procedure: Rescue extracranial stenting

• Registration Number: NCT06365294
• Lead Sponsor: Dr. Cuong Tran Chi

Brief Summary

The acute vertebrobasilar occlusion associated with the poor prognosis, particularly tandem occlusion. However, few data on the efficacy of the endovascular therapy was indicated in this occlusion. The investigators reported whether the additional rescue extracranial stenting improved clinical outcome by modified Rankin Scale (mRS) score within 3 months after the procedure

Detailed Description

Acute vertebrobasilar artery occlusion is one of the cerebrovascular diseases with high disability and mortality rates. Although mechanical thrombectomy has recently been demonstrated an effective treatment for large vessel occlusions of posterior circulation, the treatment strategies depending on the specific pathophysiology. Tandem occlusion in posterior circulation is less frequently than in anterior one, comprises severe stenosis or occlusion of the extracranial vertebral artery ipsilateral to its intracranial and basilar occlusion. The recent studies showed the benefit of the "distal-to-proximal" approach, there were many tecniques to achieved the successful recanalization. Besides, the use of Dotter technique allowed 8F guiding catheter to cross the extracranial lesions easily and save the procedural time. However, the Diagnosis 5F-Dotter, like the Dilator-Dotter, has not been mentioned in previous studies. Therefore, the aim of the our study was to assess the improvement of outcomes at 3 months posttreatment in patients receiving rescue extracranial vertebral stenting

Study Timeline

• Study Start: 2020-12-31
• Study First Submitted: 2024-04-10
• Study First Submitted QC: 2024-04-10
• Study First Posted: 2024-04-15
• Primary Completion: 2024-04-30
• Status Verified: 2024-06
• Study Completion: 2024-06-08
• Last Update Submitted: 2024-06-09
• Last Update Posted: 2024-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• Age > 18 years old
• Onset to treatment time < 24 hours
• NIHSS > 5
• pc-ASPECTS ≥ 5

Exclusion Criteria

• Premorbid mRS > 2
• Extensive, bilateral brain-stem infarction on neuroimaging
• Cerebellar mass effect on neuroimaging
• Loss to follow-up

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Rescue extracranial vertebral stenting	Rescue extracranial stenting	Rescue extracranial vertebral stenting in tandem occlusions

Primary Outcome Measures

Name	Time	Method
The good 3-month outcome rate	3 months	The good 3-month outcome rate was accessed by modified Rankin Score (mRS ≤ 2).

Trial Locations

Locations (1)

Can Tho SIS Hospital; 🇻🇳 Cần Thơ, Vietnam