Suitability of 11C-ORM-13070 as a PET Tracer

Recruitment & Eligibility

Inclusion Criteria

Good general health ascertained by detailed medical history and physical examination
Males between 18 and 45 years
Body mass index (BMI) between 18-30 kg/m2
Weight 55-95 kg (inclusive)

Exclusion Criteria

Evidence of clinically significant cardiovascular, renal, hepatic, haematological, gastro-intestinal, pulmonary, metabolic-endocrine, neurological, urogenital or psychiatric disease as judged by the investigator
Any condition requiring regular concomitant medication including herbal products or likely to need any concomitant medication during the study.
Regular consumption of more than 21 units of alcohol per week (1 unit = 4 cl spirits, about 13 g of alcohol)
Current use of nicotine-containing products more than 5 cigarettes or equivalent/day
Inability to refrain from using nicotine-containing products during the stay in the study centre
Inability to refrain from consuming caffeine-containing beverages during the stay in the study centre e.g. propensity in getting headache when refraining from caffeine-containing beverages
Blood donation or loss of significant amount of blood within 3 months prior to the screening visit
Abnormal 12-lead electrocardiogram (ECG) finding of clinical relevance
Any abnormal value of laboratory, vital signs, or physical examination, which may in the opinion of the investigator interfere with the interpretation of the test results or cause a health risk for the subject if he takes part into the study
Anatomical abnormality in MRI which may in the opinion of the investigator interfere with the interpretation of PET results
Participation in a drug study within 3 months prior to the entry into this study
Participation in a prior PET study

Arm && Interventions

Group	Intervention	Description
11C-ORM-13070	11C-ORM-13070	-

Primary Outcome Measures

Name	Time	Method
Suitability of 11C-ORM-13070 as a PET tracer	1 day

Secondary Outcome Measures

Name	Time	Method