Tiotropium / Respimat One Year Study in COPD.

Phase 3

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

Interventions: Device: Respimat
Drug: Tiotropium

Registration Number: NCT00387088

Lead Sponsor: Boehringer Ingelheim

Brief Summary: The objective of the study is to evaluate the long-term (one year) efficacy and safety of tiotropium delivered by the Respimat inhaler in patients with COPD. Specifically, the study will examine the effect of treatment on COPD exacerbations.

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 3991

Inclusion Criteria

Male or female
At least 40 years old
Smoker or ex-smoker
Smoking history > 10 pack-years
Forced Expiratory Volume in 1 Second (FEV1) < 60% predicted

Exclusion Criteria

Recent history of myocardial infarction, life-threatening cardiac arrhythmia or hospitalisation for cardiac failure
History of asthma or allergic conditions.
Malignancy requiring treatment within past 5 years
Life-threatening pulmonary obstruction, cystic fibrosis or clinically evident bronchiectasis
Known active tuberculosis
Known hypersensitivity to anticholinergic drugs.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Respimat	Placebo via Respimat® inhaler (2 inhalations per day) + usual maintenance treatment (only anticholinergic bronchodilators were excluded)
Tiotropium	Tiotropium	Tiotropium 5µg via Respimat® inhaler (2 inhalations of 2.5µg per day) + usual maintenance treatment (only anticholinergic bronchodilators were excluded)

Primary Outcome Measures

Name	Time	Method
Change From Baseline in Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 337	Baseline and Day 337	Trough FEV1 is defined as the FEV1 measured at the -10 min time point at the end of the dosing interval (24 h post drug administration).
Time to First Chronic Obstructive Pulmonary Disease (COPD) Exacerbation	During actual study treatment period (planned Day 1 to Day 337)	Time to first COPD exacerbation (defined as a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment). Time is days from start of study treatment to onset of exacerbation.

Secondary Outcome Measures

Name	Time	Method
Change From Baseline in Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 29	Baseline and Day 29	Trough FEV1 is the mean volume of air that can be forced out in one second after taking a deep breath approximately 24 hours after the last administration of study drug.
Change From Baseline in Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 169	Baseline and Day 169	Trough FEV1 is the mean volume of air that can be forced out in one second after taking a deep breath approximately 24 hours after the last administration of study drug.
Number of COPD Exacerbations Per Patient - Exposure Adjusted	During actual study treatment period (planned Day 1 to Day 337)	Number of COPD exacerbations (defined as a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment) per patient adjusted by length of treatment exposure (i.e. number of exacerbations multiplied by 365.25 and then divided by days of treatment exposure)
Number of COPD Exacerbations Per Patient - naïve Estimate	During actual study treatment period (planned Day 1 to Day 337)	Number of COPD exacerbations (defined as a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment) per patient not adjusted for treatment exposure (i.e. naïve estimate)
Number of Patients With at Least One COPD Exacerbation	During actual study treatment period (planned Day 1 to Day 337)	Number of patients with at least one COPD exacerbation (defined as a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment)
Time to First Hospitalisation for COPD Exacerbation	During actual study treatment period (planned Day 1 to Day 337)	Time to first hospitalisation for COPD exacerbation (a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment). Time is days from start of study treatment to onset of exacerbation
Number of Hospitalisations for COPD Exacerbations Per Patient - Exposure Adjusted	During actual study treatment period (planned Day 1 to Day 337)	Number of hospitalisations for COPD exacerbations (a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment) per patient adjusted by length of treatment exposure (i.e. no. of exacerbations multiplied by 365.25 and then divided by days of treatment exposure)
Number of Hospitalisations for COPD Exacerbations Per Patient - naïve Estimate	During actual study treatment period (planned Day 1 to Day 337)	Number of hospitalisations for COPD exacerbations (a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment) per patient not adjusted for treatment exposure (i.e. naïve estimate)
Number of Patients With at Least One Hospitalisation for a COPD Exacerbation	During actual study treatment period (planned Day 1 to Day 337)	Number of patients with at least one hospitalisation for a COPD exacerbation (a complex of respiratory events/symptoms (increase or new onset) with a duration of 3 days or more requiring a change in treatment)
Change From Baseline in Saint George's Respiratory Questionnaire (SGRQ) Total Score at Day 337	Baseline and Day 337	The SGRQ total score measures quality of life on a continuous scale ranging from 0=best state to 100=worst state
Change From Baseline in Saint George's Respiratory Questionnaire (SGRQ) Total Score at Day 169	Baseline and Day 169	The SGRQ total score measures quality of life on a continuous scale ranging from 0=best state to 100=worst state
Change From Baseline in Saint George's Respiratory Questionnaire (SGRQ) Domain Score at Day 337	Baseline and Day 337	The SGRQ domain score (symptom, activity and impact) measures quality of life on a continuous scale ranging from 0=best state to 100=worst state
Change From Baseline in Saint George's Respiratory Questionnaire (SGRQ) Domain Score at Day 169	Baseline and Day 169	The SGRQ domain score (symptom, activity and impact) measures quality of life on a continuous scale ranging from 0=best state to 100=worst state
Change From Baseline in Trough Forced Vital Capacity (FVC) at Day 29	Baseline and Day 29	Trough FVC is the mean maximum volume of air that can be forcibly expired from the lungs; measured approximately 24 hours after the last administration of study drug.
Change From Baseline in Trough Forced Vital Capacity (FVC) at Day 169	Baseline and Day 169	Trough FVC is the mean maximum volume of air that can be forcibly expired from the lungs; measured approximately 24 hours after the last administration of study drug.
Change From Baseline in Trough Forced Vital Capacity (FVC) at Day 337	Baseline and Day 337	Trough FVC is the mean maximum volume of air that can be forcibly expired from the lungs; measured approximately 24 hours after the last administration of study drug.
Marked Changes From Baseline in Vital Signs at End of Treatment	Baseline and end of treatment	Marked changes from baseline in vital signs (diastolic and systolic blood pressure (DBP and SBP) and pulse rate (PR)) at end of treatment. SBP - Increase means SBP \>150 mmHg and an increase above baseline of \>25 mmHg. SBP - Decrease means SBP \<100 mmHg and a decrease below baseline of \>10 mmHg. DBP - Increase means DBP \>90 mmHg and an increase above baseline of \>10 mmHg. DBP - Decrease means DBP \<60 mmHg and a decrease below baseline of \>10 mmHg. PR - Increase means PR \>100 bpm and an increase above baseline of \>10 bpm. PR - Decrease means PR \<60 bpm and a decrease below baseline of \>10 bpm.
Clinically Relevant Findings in Physical Examination and ECG	End of treatment	Clinically relevant findings in Physical Examination and ECG at end of treatment

Trial Locations

Locations (334): 205.372.01028 Boehringer Ingelheim Investigational Site
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Rancho Mirage, California, United States
205.372.01060 Boehringer Ingelheim Investigational Site
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Clearwater, Florida, United States
205.372.01008 Boehringer Ingelheim Investigational Site
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Norwalk, Connecticut, United States
205.372.01053 Boehringer Ingelheim Investigational Site
🇺🇸
Winter Park, Florida, United States
205.372.01030 Boehringer Ingelheim Investigational Site
🇺🇸
Syracuse, New York, United States
205.372.86001 Boehringer Ingelheim Investigational Site
🇨🇳
Guangzhou, China
205.372.86005 Boehringer Ingelheim Investigational Site
🇨🇳
Shenyang, China
205.372.01035 Boehringer Ingelheim Investigational Site
🇺🇸
Wichita, Kansas, United States
205.372.61003 Sir Charles Gairdner Hospital
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Nedlands, Western Australia, Australia
205.372.01043 Boehringer Ingelheim Investigational Site
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Normal, Illinois, United States
205.372.01059 Boehringer Ingelheim Investigational Site
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Long Beach, California, United States
205.372.01062 Boehringer Ingelheim Investigational Site
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Mobile, Alabama, United States
205.372.01037 Boehringer Ingelheim Investigational Site
🇺🇸
Huntington Park, California, United States
205.372.01007 Boehringer Ingelheim Investigational Site
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Los Angeles, California, United States
205.372.01023 Boehringer Ingelheim Investigational Site
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West Palm Beach, Florida, United States
205.372.11012 West Lincoln Memorial Hospital
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Grimsby, Ontario, Canada
205.372.86002 Boehringer Ingelheim Investigational Site
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Beijing, China
205.372.55011 CEDOES - Diagnóstico e Pesquisa
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Vitória, Brazil
205.372.86004 Boehringer Ingelheim Investigational Site
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Beijing, China
205.372.86009 Boehringer Ingelheim Investigational Site
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Chengdu, Sichuan Province, China
205.372.55010 Unidade de Coracao e Pulmao do Dto. de Medicina
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São Paulo - SP, Brazil
205.372.11005 Professional Corp. Respirology
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Saint John, New Brunswick, Canada
205.372.11001 Niagara Clinical Research
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Niagara Falls, Ontario, Canada
205.372.86010 Boehringer Ingelheim Investigational Site
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Shanghai, China
205.372.86012 Boehringer Ingelheim Investigational Site
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Shanghai, China
205.372.11003 London Road Diagnostic Clinic and Medical Centre
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Sarnia, Ontario, Canada
205.372.11002 Centenary Respiratory Research Associates
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Scarborough, Ontario, Canada
205.372.11014 Dr. Robert Luton
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London, Ontario, Canada
205.372.86011 Boehringer Ingelheim Investigational Site
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Shanghai, China
205.372.3318B Clinique du Parc
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Castelnau le Lez, France
205.372.11017 Boehringer Ingelheim Investigational Site
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Edmonton, Alberta, Canada
205.372.11016 London Road Diagnostic Clinic and Medical Centre
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Sarnia, Ontario, Canada
205.372.86008 Boehringer Ingelheim Investigational Site
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Chongqing, China
205.372.3303B Hôpital Notre Dame de Bon Secours
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Metz cedex 1, France
205.372.3315A Hôpital Caremeau
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Nîmes, France
205.372.11019 Allergy and Asthma Research Centre
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Ottawa, Ontario, Canada
205.372.86003 Boehringer Ingelheim Investigational Site
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Beijing, China
205.372.36005 Boehringer Ingelheim Investigational Site
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Erd, Hungary
205.372.49008 Boehringer Ingelheim Investigational Site
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Bruchsal, Germany
205.372.35804 Boehringer Ingelheim Investigational Site
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Helsinki, Finland
205.372.3312B Cabinet Médical
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Montigny les Metz, France
205.372.49011 Boehringer Ingelheim Investigational Site
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Frankfurt/Main, Germany
205.372.49004 Boehringer Ingelheim Investigational Site
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Berlin, Germany
205.372.3302A Centre Médical Erdre Saint Augustin
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Nantes, France
205.372.49013 Boehringer Ingelheim Investigational Site
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Berlin, Germany
205.372.49009 Boehringer Ingelheim Investigational Site
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Minden, Germany
205.372.49002 Boehringer Ingelheim Investigational Site
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Berlin, Germany
205.372.30002 Boehringer Ingelheim Investigational Site
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Athens, Greece
205.372.3320A Polyclinique Les Fleurs
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Ollioules, France
205.372.30014 Boehringer Ingelheim Investigational Site
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Thiva, Greece
205.372.49012 Boehringer Ingelheim Investigational Site
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Gelnhausen, Germany
205.372.49007 Boehringer Ingelheim Investigational Site
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Bonn, Germany
205.372.60003 Boehringer Ingelheim Investigational Site
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Penang, Malaysia
205.372.82007 Boehringer Ingelheim Investigational Site
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Kwangju, Korea, Republic of
205.372.52012 Hospital de Nuestra Señora de la Salud
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San Luis Potosi, Mexico
205.372.88603 Mackay Memorial Hospital
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Taipei, Taiwan
205.372.88602 Taipei Veterans General Hospital
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Taipei, Taiwan
205.372.88604 Tri-Service General Hospital
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Taipei, Taiwan
205.372.88608 Boehringer Ingelheim Investigational Site
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Taipei, Taiwan
205.372.47002 Boehringer Ingelheim Investigational Site
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Ålesund, Norway
205.372.45002 Boehringer Ingelheim Investigational Site
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Hvidovre, Denmark
205.372.45001 Boehringer Ingelheim Investigational Site
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København NV, Denmark
205.372.39007 Boehringer Ingelheim Investigational Site
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Bussolengo (vr), Italy
205.372.39005 Boehringer Ingelheim Investigational Site
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Milano, Italy
205.372.39008 Boehringer Ingelheim Investigational Site
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Modena, Italy
205.372.39001 Boehringer Ingelheim Investigational Site
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Pisa, Italy
205.372.39002 Boehringer Ingelheim Investigational Site
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Prato (fi), Italy
205.372.39011 Boehringer Ingelheim Investigational Site
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Roma, Italy
205.372.39006 Boehringer Ingelheim Investigational Site
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Trieste, Italy
205.372.01012 Boehringer Ingelheim Investigational Site
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Birmingham, Alabama, United States
205.372.01020 Boehringer Ingelheim Investigational Site
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Birmingham, Alabama, United States
205.372.01011 Boehringer Ingelheim Investigational Site
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San Diego, California, United States
205.372.01003 Boehringer Ingelheim Investigational Site
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Minneapolis, Minnesota, United States
205.372.01044 Boehringer Ingelheim Investigational Site
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Cincinnati, Ohio, United States
205.372.3318A Clinique du Parc
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Castelnau le Lez, France
205.372.3320B Polyclinique Les Fleurs
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Ollioules, France
205.372.3316B Clinique les Bleuets
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Reims, France
205.372.3312A Cabinet Médical
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Montigny les Metz, France
205.372.3305B Cabinet Médical
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Nice, France
205.372.3325A Cabinet Médical
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Six Four les Plages, France
205.372.3319A Institut Arnault Tzanck
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Saint Laurent du Var, France
205.372.3321C Centre Hospitalier
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St Gaudens, France
205.372.3324A Cabinet Médical
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Toulon, France
205.372.3309A Cabinet médical
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Toulouse, France
205.372.3309B Cabinet médical
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Toulouse, France
205.372.44016 Boehringer Ingelheim Investigational Site
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Isleworth, United Kingdom
205.372.55005 Hospital Geral Otávio de Freitas
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Recife, Brazil
205.372.55001 INCOR e Hospital das Clínicas da Universidade de São Paulo
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São Paulo - SP, Brazil
205.372.55009 Hospital das Clínicas de Goiânia
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Goiânia, Brazil
205.372.49014 Boehringer Ingelheim Investigational Site
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Hannover, Germany
205.372.49005 Boehringer Ingelheim Investigational Site
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Kassel, Germany
205.372.49016 Boehringer Ingelheim Investigational Site
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Weinheim, Germany
205.372.49015 Boehringer Ingelheim Investigational Site
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Weyhe, Germany
205.372.49001 Boehringer Ingelheim Investigational Site
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Wiesloch, Germany
205.372.01036 Boehringer Ingelheim Investigational Site
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Omaha, Nebraska, United States
205.372.61006 The Investigator Clinic
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Port Lincoln, South Australia, Australia
205.372.01058 Boehringer Ingelheim Investigational Site
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Long Beach, California, United States
205.372.01048 Boehringer Ingelheim Investigational Site
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Berkeley, California, United States
205.372.01004 Boehringer Ingelheim Investigational Site
🇺🇸
Brandon, Florida, United States
205.372.01066 Boehringer Ingelheim Investigational Site
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Boulder, Colorado, United States
205.372.01045 Boehringer Ingelheim Investigational Site
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Calhoun, Georgia, United States
205.372.01049 Boehringer Ingelheim Investigational Site
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Shreveport, Louisiana, United States
205.372.01061 Boehringer Ingelheim Investigational Site
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Dubuque, Iowa, United States
205.372.01015 Boehringer Ingelheim Investigational Site
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Biddeford, Maine, United States
205.372.01067 Boehringer Ingelheim Investigational Site
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Columbia, Maryland, United States
205.372.01006 Boehringer Ingelheim Investigational Site
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Rockville, Maryland, United States
205.372.01014 Boehringer Ingelheim Investigational Site
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St. Louis, Missouri, United States
205.372.01021 Boehringer Ingelheim Investigational Site
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Chesterfield, Missouri, United States
205.372.01024 Boehringer Ingelheim Investigational Site
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Mineola, New York, United States
205.372.01029 Boehringer Ingelheim Investigational Site
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Rochester, New York, United States
205.372.01046 Boehringer Ingelheim Investigational Site
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Albuquerque, New Mexico, United States
205.372.01026 Boehringer Ingelheim Investigational Site
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Chapel Hill, North Carolina, United States
205.372.01027 Boehringer Ingelheim Investigational Site
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Elizabeth City, North Carolina, United States
205.372.01019 Boehringer Ingelheim Investigational Site
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Charlotte, North Carolina, United States
205.372.01031 Boehringer Ingelheim Investigational Site
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Winston-Salem, North Carolina, United States
205.372.01038 Boehringer Ingelheim Investigational Site
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Raleigh, North Carolina, United States
205.372.01017 Boehringer Ingelheim Investigational Site
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Cincinnati, Ohio, United States
205.372.01001 Boehringer Ingelheim Investigational Site
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Oklahoma City, Oklahoma, United States
205.372.01068 Boehringer Ingelheim Investigational Site
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Philadelphia, Pennsylvania, United States
205.372.01056 Boehringer Ingelheim Investigational Site
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Swathmore, Pennsylvania, United States
205.372.01050 Boehringer Ingelheim Investigational Site
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Dallas, Texas, United States
205.372.01018 Boehringer Ingelheim Investigational Site
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Killeen, Texas, United States
205.372.01040 Boehringer Ingelheim Investigational Site
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New Braunfels, Texas, United States
205.372.01005 Boehringer Ingelheim Investigational Site
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Fort Worth, Texas, United States
205.372.01052 Boehringer Ingelheim Investigational Site
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San Antonio, Texas, United States
205.372.01022 Boehringer Ingelheim Investigational Site
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Danville, Virginia, United States
205.372.01055 Boehringer Ingelheim Investigational Site
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Richmond, Virginia, United States
205.372.61002 Woolcock Institute of Medical Research
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Glebe, New South Wales, Australia
205.372.61009 Thoracic & General Physician
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Cairns, Queensland, Australia
205.372.61005 Redcliffe Hospital
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Redcliffe, Queensland, Australia
205.372.61007 The Burnside War Memorial Hospital
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Toorak Gardens, South Australia, Australia
205.372.61004 Boehringer Ingelheim Investigational Site
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Woodville, South Australia, Australia
205.372.61010 Ecru
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Box Hill, Victoria, Australia
205.372.61001 Emeritus Research
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Malvern, Victoria, Australia
205.372.55012 Universidade Federal de Santa Catarina
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Florianópolis, Brazil
205.372.11007 Heritage Medical Research Building
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Calgary, Alberta, Canada
205.372.11010 Dr. Kay Ho
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Chilliwack, British Columbia, Canada
205.372.11020 Wetaskiwin Lung Laboratory
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Wetaskiwin, Alberta, Canada
205.372.11006 Clinique de médecine familiale de La Malbaie
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La Malbaie, Quebec, Canada
205.372.86007 Boehringer Ingelheim Investigational Site
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Wuhan, China
205.372.86006 Boehringer Ingelheim Investigational Site
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Shenyang, China
205.372.45004 Boehringer Ingelheim Investigational Site
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Aarhus C, Denmark
205.372.45005 Boehringer Ingelheim Investigational Site
🇩🇰
Horsens, Denmark
205.372.45003 Boehringer Ingelheim Investigational Site
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Odense C, Denmark
205.372.3304A Cabinet Médical
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Chamalières, France
205.372.45006 Boehringer Ingelheim Investigational Site
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Silkeborg, Denmark
205.372.3301A Hôpital Gabriel Montpied
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Clermont Ferrand cedex 1, France
205.372.3310A Centre Hospitalier
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Denain, France
205.372.3306A Hôpital Ambroise Paré
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Marseille, France
205.372.3314A Cabinet Médical
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Grasse, France
205.372.3303A Hôpital Notre Dame de Bon Secours
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Metz cedex 1, France
205.372.3305A Cabinet Médical
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Nice, France
205.372.3317A Cabinet de Pneumologie
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Nîmes, France
205.372.3315B Hôpital Caremeau
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Nimes cedex 9, France
205.372.3316A Clinique les Bleuets
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Reims, France
205.372.3321A Centre Hospitalier
🇫🇷
St Gaudens, France
205.372.49006 Boehringer Ingelheim Investigational Site
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Gütersloh, Germany
205.372.49003 Boehringer Ingelheim Investigational Site
🇩🇪
Witten, Germany
205.372.30001 Boehringer Ingelheim Investigational Site
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Athens, Greece
205.372.30013 Boehringer Ingelheim Investigational Site
🇬🇷
Athens, Greece
205.372.30004 Boehringer Ingelheim Investigational Site
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Komotini, Greece
205.372.30007 Boehringer Ingelheim Investigational Site
🇬🇷
Kalamaria, Greece
205.372.30005 Boehringer Ingelheim Investigational Site
🇬🇷
Kavala, Greece
205.372.30015 Boehringer Ingelheim Investigational Site
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Athens, Greece
205.372.30009 Boehringer Ingelheim Investigational Site
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Heraklion-Crete, Greece
205.372.30011 Boehringer Ingelheim Investigational Site
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Korinthos, Greece
205.372.30019 Boehringer Ingelheim Investigational Site
🇬🇷
Nafplio, Greece
205.372.30008 Boehringer Ingelheim Investigational Site
🇬🇷
Serres, Greece
205.372.30006 Boehringer Ingelheim Investigational Site
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Thessaloniki, Greece
205.372.30017 Boehringer Ingelheim Investigational Site
🇬🇷
Thessaloniki, Greece
205.372.85201 Boehringer Ingelheim Investigational Site
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Kowloon, Hong Kong
205.372.36001 Boehringer Ingelheim Investigational Site
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Budapest, Hungary
205.372.36002 Boehringer Ingelheim Investigational Site
🇭🇺
Debrecen, Hungary
205.372.36004 Boehringer Ingelheim Investigational Site
🇭🇺
Deszk, Hungary
205.372.91016 Boehringer Ingelheim Investigational Site
🇮🇳
Andhra Pradesh, India
205.372.36006 Boehringer Ingelheim Investigational Site
🇭🇺
Mosonmagyarovar, Hungary
205.372.36007 Boehringer Ingelheim Investigational Site
🇭🇺
Sopron, Hungary
205.372.91005 Boehringer Ingelheim Investigational Site
🇮🇳
Andhra Pradesh, India
205.372.91003 Boehringer Ingelheim Investigational Site
🇮🇳
Bangalore, India
205.372.91017 Boehringer Ingelheim Investigational Site
🇮🇳
Calicut,Kerala, India
205.372.91010 Boehringer Ingelheim Investigational Site
🇮🇳
Chennai, India
205.372.91002 Boehringer Ingelheim Investigational Site
🇮🇳
Coimbatore, India
205.372.91011 Boehringer Ingelheim Investigational Site
🇮🇳
indore,MP, India
205.372.91009 Boehringer Ingelheim Investigational Site
🇮🇳
Gujarat, India
205.372.91004 Boehringer Ingelheim Investigational Site
🇮🇳
Mumbai, India
205.372.91008 Boehringer Ingelheim Investigational Site
🇮🇳
Mumbai, India
205.372.91015 Boehringer Ingelheim Investigational Site
🇮🇳
New Delhi, India
205.372.91001 Boehringer Ingelheim Investigational Site
🇮🇳
Uttar Pradesh, India
205.372.35303 Boehringer Ingelheim Investigational Site
🇮🇪
Mullingar, Ireland
205.372.91014 Boehringer Ingelheim Investigational Site
🇮🇳
Punjab, India
205.372.91013 Boehringer Ingelheim Investigational Site
🇮🇳
Tamil Nadu, India
205.372.39012 Boehringer Ingelheim Investigational Site
🇮🇹
Ferrara, Italy
205.372.39004 Boehringer Ingelheim Investigational Site
🇮🇹
Genova, Italy
205.372.39003 Boehringer Ingelheim Investigational Site
🇮🇹
Genova, Italy
205.372.39009 Boehringer Ingelheim Investigational Site
🇮🇹
Orbassano (to), Italy
205.372.39010 Boehringer Ingelheim Investigational Site
🇮🇹
Pordenone, Italy
205.372.82010 Boehringer Ingelheim Investigational Site
🇰🇷
Anyang, Korea, Republic of
205.372.82008 Boehringer Ingelheim Investigational Site
🇰🇷
Jeonbuk, Korea, Republic of
205.372.82005 Boehringer Ingelheim Investigational Site
🇰🇷
Daegu, Korea, Republic of
205.372.82009 Boehringer Ingelheim Investigational Site
🇰🇷
Daejoen, Korea, Republic of
205.372.82003 Boehringer Ingelheim Investigational Site
🇰🇷
Incheon, Korea, Republic of
205.372.82001 Boehringer Ingelheim Investigational Site
🇰🇷
Seoul, Korea, Republic of
205.372.82002 Boehringer Ingelheim Investigational Site
🇰🇷
Pusan, Korea, Republic of
205.372.82006 Boehringer Ingelheim Investigational Site
🇰🇷
Seoul, Korea, Republic of
205.372.82004 Boehringer Ingelheim Investigational Site
🇰🇷
Seoul, Korea, Republic of
205.372.37001 Boehringer Ingelheim Investigational Site
🇱🇹
Kaunas, Lithuania
205.372.60007 Boehringer Ingelheim Investigational Site
🇲🇾
Johor Baharu, Malaysia
205.372.37002 Boehringer Ingelheim Investigational Site
🇱🇹
Vilnius, Lithuania
205.372.60004 Boehringer Ingelheim Investigational Site
🇲🇾
Kelantan Darul Naim, Malaysia
205.372.60005 Boehringer Ingelheim Investigational Site
🇲🇾
Kuala Lumpur, Malaysia
205.372.60006 Boehringer Ingelheim Investigational Site
🇲🇾
Kuala Lumpur, Malaysia
205.372.60002 Boehringer Ingelheim Investigational Site
🇲🇾
Kuching, Sarawak, Malaysia
205.372.52018 Hospital Universitario de Chihuahua
🇲🇽
Chihuahua, Mexico
205.372.52013 Sanatorio Henri Dunant
🇲🇽
Cuernavaca, Mor. México, Mexico
205.372.60001 Boehringer Ingelheim Investigational Site
🇲🇾
Selangor, Malaysia
205.372.52017 Instituto Nacional de Enfermedades Respiratorias (INER)
🇲🇽
Col. Seccion XVI, Mexico
205.372.52009 Hospital Civil Antiguo
🇲🇽
Guadalajara Jal., Mexico
205.372.37003 Boehringer Ingelheim Investigational Site
🇱🇹
Kaunas, Lithuania
205.372.52005 Hospital Civil Nuevo de Guadalajara
🇲🇽
Guadalajara, Mexico
205.372.52004 Clínica de Mérida
🇲🇽
Merida Yuc., Mexico
205.372.52001 Hospital General del Estado de Sonora
🇲🇽
Hermosillo, Sonora, Mexico
205.372.52014 Hospital Angeles de las Lomas
🇲🇽
Huixquilucan Edo.Mex., Mexico
205.372.52002 Unidad de Investigación clínica en Medicina
🇲🇽
Monterrey, Nuevo León, Mexico
205.372.52010 Hospital General Agustin O´Haran
🇲🇽
Mérida Yucatán, Mexico
205.372.52003 Hospital "Angel Leaño"
🇲🇽
Zapopan, Jal., Mexico
205.372.31009 Boehringer Ingelheim Investigational Site
🇳🇱
Amsterdam, Netherlands
205.372.31006 Boehringer Ingelheim Investigational Site
🇳🇱
Drachten, Netherlands
205.372.31001 Boehringer Ingelheim Investigational Site
🇳🇱
Groningen, Netherlands
205.372.31007 Boehringer Ingelheim Investigational Site
🇳🇱
Leeuwarden, Netherlands
205.372.31011 Boehringer Ingelheim Investigational Site
🇳🇱
Hoofddorp, Netherlands
205.372.31004 Boehringer Ingelheim Investigational Site
🇳🇱
Roosendaal, Netherlands
205.372.31002 Boehringer Ingelheim Investigational Site
🇳🇱
Voorburg, Netherlands
205.372.31003 Boehringer Ingelheim Investigational Site
🇳🇱
Sneek, Netherlands
205.372.31012 Boehringer Ingelheim Investigational Site
🇳🇱
Utrecht, Netherlands
205.372.31008 Boehringer Ingelheim Investigational Site
🇳🇱
Weerselo, Netherlands
205.372.34004 Hospital Gregorio Marañón
🇪🇸
Madrid, Spain
205.372.47001 Boehringer Ingelheim Investigational Site
🇳🇴
Sandvika, Norway
205.372.31005 Boehringer Ingelheim Investigational Site
🇳🇱
Winschoten, Netherlands
205.372.47003 Boehringer Ingelheim Investigational Site
🇳🇴
Trondheim, Norway
205.372.35101 Hospital Pulido Valente
🇵🇹
Lisboa, Portugal
205.372.35102 Hospital Fernando Fonseca
🇵🇹
Amadora, Portugal
205.372.35105 Centro Hospitalar do Alto Minho, Estrada de Santa Luzia
🇵🇹
Viana do Castelo, Portugal
205.372.65003 Boehringer Ingelheim Investigational Site
🇸🇬
Singapore, Singapore
205.372.35103 Hospital de São João
🇵🇹
Porto, Portugal
205.372.65001 Boehringer Ingelheim Investigational Site
🇸🇬
Singapore, Singapore
205.372.65005 Boehringer Ingelheim Investigational Site
🇸🇬
Singapore, Singapore
205.372.42102 Boehringer Ingelheim Investigational Site
🇸🇰
Bratislava, Slovakia
205.372.42103 Boehringer Ingelheim Investigational Site
🇸🇰
Nove Zamky, Slovakia
205.372.27002 Boehringer Ingelheim Investigational Site
🇿🇦
Bellville, South Africa
205.372.27004 Boehringer Ingelheim Investigational Site
🇿🇦
Cape Town, South Africa
205.372.27001 Boehringer Ingelheim Investigational Site
🇿🇦
Cape Town, South Africa
205.372.27008 Boehringer Ingelheim Investigational Site
🇿🇦
Cape Town, South Africa
205.372.27003 Boehringer Ingelheim Investigational Site
🇿🇦
Durban, South Africa
205.372.27006 Boehringer Ingelheim Investigational Site
🇿🇦
Centurion, South Africa
205.372.27005 Boehringer Ingelheim Investigational Site
🇿🇦
Pretoria, South Africa
205.372.27007 Boehringer Ingelheim Investigational Site
🇿🇦
Somerset West, South Africa
205.372.34005 Hospital San Pedro de Alcántara
🇪🇸
Cáceres, Spain
205.372.34006 Hospital 12 de octubre
🇪🇸
Madrid, Spain
205.372.46001 Björknäs Vårdcentral
🇸🇪
Boden, Sweden
205.372.46004 Näsets läkargrupp
🇸🇪
Höllviken, Sweden
205.372.34002 Hospital Universitario Dr. Peset
🇪🇸
Valencia, Spain
205.372.46002 Alnö Vårdcentral
🇸🇪
Sundsvall, Sweden
205.372.46005 Lungmedicinska kliniken
🇸🇪
Linköping, Sweden
205.372.46006 Lungmedicinska Kliniken
🇸🇪
Stockholm, Sweden
205.372.41002 Boehringer Ingelheim Investigational Site
🇨🇭
Lugano, Switzerland
205.372.41003 Boehringer Ingelheim Investigational Site
🇨🇭
Montana, Switzerland
205.372.88607 Kaohsiung Medical University Hospital
🇨🇳
Kaohsiung, Taiwan
205.372.88601 National Taiwan University Hospital
🇨🇳
Taipei, Taiwan
205.372.88606 National Cheng Kung University Hospital
🇨🇳
Tainan, Taiwan
205.372.88605 Chang Gung Memorial Hosp-Linkou
🇨🇳
Taoyuan, Taiwan
205.372.90006 Gazi Universitesi Tip Fakultesi Gogus Hastaliklari A.B.D.
🇹🇷
Ankara, Turkey
205.372.88609 Boehringer Ingelheim Investigational Site
🇨🇳
Taipei, Taiwan
205.372.90009 Trakya Universitesi Tip Fakultesi Gogus Hastaliklari A.B.D.
🇹🇷
Edirne, Turkey
205.372.90004 Dr. Lütfi Kirdar Egitim ve Arastirma Hastanesi
🇹🇷
Istanbul, Turkey
205.372.90001 Izmir Tepecik Gogus Hastaliklari ve Gogus Cerrahisi Hast.
🇹🇷
Izmir, Turkey
205.372.44002 Boehringer Ingelheim Investigational Site
🇬🇧
Chertsey, United Kingdom
205.372.44027 Boehringer Ingelheim Investigational Site
🇬🇧
Aston Clinton, Aylesbury, United Kingdom
205.372.90008 Erciyes Universitesi Tip Fakultesi
🇹🇷
Kayseri, Turkey
205.372.90010 Selcuk Universitesi Tip Fakultesi
🇹🇷
Konya, Turkey
205.372.44023 Boehringer Ingelheim Investigational Site
🇬🇧
Chesterfield, United Kingdom
205.372.44022 Boehringer Ingelheim Investigational Site
🇬🇧
Carmarthen, United Kingdom
205.372.44014 Boehringer Ingelheim Investigational Site
🇬🇧
Darlington, United Kingdom
205.372.44009 Boehringer Ingelheim Investigational Site
🇬🇧
East Horsley, United Kingdom
205.372.44026 Boehringer Ingelheim Investigational Site
🇬🇧
Greenisland, United Kingdom
205.372.44011 Boehringer Ingelheim Investigational Site
🇬🇧
Fowey, United Kingdom
205.372.44003 Boehringer Ingelheim Investigational Site
🇬🇧
Frome, United Kingdom
205.372.44013 Boehringer Ingelheim Investigational Site
🇬🇧
Heywood, United Kingdom
205.372.44020 Boehringer Ingelheim Investigational Site
🇬🇧
Kirkby in Ashfield, United Kingdom
205.372.44024 Boehringer Ingelheim Investigational Site
🇬🇧
Mortimer, United Kingdom
205.372.44001 Boehringer Ingelheim Investigational Site
🇬🇧
Nottingham, United Kingdom
205.372.44018 Boehringer Ingelheim Investigational Site
🇬🇧
Penzance, United Kingdom
205.372.44021 Boehringer Ingelheim Investigational Site
🇬🇧
Plymouth, United Kingdom
205.372.44007 Boehringer Ingelheim Investigational Site
🇬🇧
Sheffield, United Kingdom
205.372.44010 Boehringer Ingelheim Investigational Site
🇬🇧
Sneinton, Nottingham, United Kingdom
205.372.44005 Boehringer Ingelheim Investigational Site
🇬🇧
St Just, Penzance, United Kingdom
205.372.44015 Boehringer Ingelheim Investigational Site
🇬🇧
St. Austell, United Kingdom
205.372.44008 Boehringer Ingelheim Investigational Site
🇬🇧
Wellingborough, United Kingdom
205.372.44012 Boehringer Ingelheim Investigational Site
🇬🇧
Westbury on Trym, United Kingdom
205.372.44028 Boehringer Ingelheim Investigational Site
🇬🇧
Windsor, United Kingdom
205.372.44006 Boehringer Ingelheim Investigational Site
🇬🇧
Sunderland, United Kingdom
205.372.44019 Boehringer Ingelheim Investigational Site
🇬🇧
Woking, United Kingdom
205.372.34001 Hospital Mutua Terrassa
🇪🇸
Terrassa (Barcelona), Spain
205.372.01069 Boehringer Ingelheim Investigational Site
🇺🇸
Miami Beach, Florida, United States
205.372.01065 Boehringer Ingelheim Investigational Site
🇺🇸
Lynchburg, Virginia, United States
205.372.01034 Boehringer Ingelheim Investigational Site
🇺🇸
Los Angeles, California, United States
205.372.01064 Boehringer Ingelheim Investigational Site
🇺🇸
Tacoma, Washington, United States
205.372.49010 Boehringer Ingelheim Investigational Site
🇩🇪
München, Germany
205.372.01041 Boehringer Ingelheim Investigational Site
🇺🇸
Cincinnati, Ohio, United States
205.372.01039 Boehringer Ingelheim Investigational Site
🇺🇸
Dallas, Texas, United States
205.372.35802 Boehringer Ingelheim Investigational Site
🇫🇮
Jyväskylä, Finland
205.372.35803 Boehringer Ingelheim Investigational Site
🇫🇮
Lahti, Finland
205.372.91007 Boehringer Ingelheim Investigational Site
🇮🇳
Chennai, India
205.372.35104 Hospital de Santa Marta
🇵🇹
Lisboa, Portugal
205.372.35801 Boehringer Ingelheim Investigational Site
🇫🇮
Tampere, Finland
205.372.30003 Boehringer Ingelheim Investigational Site
🇬🇷
Athens, Greece
205.372.52006 Hospital Universitario
🇲🇽
Monterrey, Nuevo León, Mexico
205.372.01013 Boehringer Ingelheim Investigational Site
🇺🇸
Detroit, Michigan, United States
205.372.61008 Geelong Clinical Research Centre
🇦🇺
Geelong, Victoria, Australia
205.372.91006 Boehringer Ingelheim Investigational Site
🇮🇳
Bangalore, India
205.372.91012 Boehringer Ingelheim Investigational Site
🇮🇳
Maharashtra, India
205.372.52016 Hospital General de Mexicali
🇲🇽
Mexicali Baja California Norte, Mexico
205.372.01063 Boehringer Ingelheim Investigational Site
🇺🇸
Eugene, Oregon, United States
205.372.11013 Calgary West Medical Centre
🇨🇦
Calgary, Alberta, Canada
205.372.11011 Hermitage Medicentre
🇨🇦
Edmonton, Alberta, Canada
205.372.11009 White Hills Medical Clinic
🇨🇦
St. John's, Newfoundland and Labrador, Canada
205.372.11004 Mount Royal Family Physicians
🇨🇦
Saskatoon, Saskatchewan, Canada
205.372.11015 Dr. Arun Nayar
🇨🇦
Saskatoon, Saskatchewan, Canada
205.372.41001 Boehringer Ingelheim Investigational Site
🇨🇭
Zürich, Switzerland
205.372.90007 Atatürk Gög. Hastaliklari ve Cerrahisi Egitim Hastanesi
🇹🇷
Ankara, Turkey
205.372.90003 Uludag Universitesi Tip Fakultesi Gogus Hastaliklari
🇹🇷
Bursa, Turkey
205.372.90005 Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷
Istanbul, Turkey
205.372.90002 19 Mayis Universitesi Tip Fakultesi Gogus Hastaliklari A.B.D
🇹🇷
Samsun, Turkey
205.372.11018 Pacific Lung Health Centre
🇨🇦
Vancouver, British Columbia, Canada
205.372.85203 Boehringer Ingelheim Investigational Site
🇭🇰
Hong Kong, Hong Kong