Prevalence of Pulmonary Embolism in Emergency Department Patients With Isolated Syncope
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 459
- 试验地点
- 2
- 主要终点
- diagnosis of Pulmonary embolism within 72 hrs after ED visit Safety
研究概览
简要总结
Syncope is a rapid onset, transient, loss of consciousness with a short duration. This symptom has been reported to be a specific presentation of patients with pulmonary embolism. However, the prevalence of pulmonary embolism in patients with syncope remains debated. This prospective cohort study will recruit patients presenting to the emergency department with a syncope, who will systematically undergo formal workup for pulmonary embolism. The main objective of this study is to assess the prevalence of pulmonary embolism in ED patients with syncope
详细描述
Syncope is a rapid onset, transient, loss of consciousness with a short duration. This symptom has been reported to be a specific presentation of patients with pulmonary embolism. However, the prevalence of pulmonary embolism in patients with syncope remains debated. This prospective cohort study will recruit patients presenting to the emergency department with a syncope, who will systematically undergo formal workup for pulmonary embolism. The main objective of this study is to assess the prevalence of pulmonary embolism in ED patients with syncope
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >= 18 years visiting the Emergency Department,
- •history of syncope in the past 24 hours: loss of consciousness, rapid onset, short duration (<1 min), transient, with spontaneous and rapid recovery without post event confusion
- •With or without prodromes
- •Without any other obvious cause
- •Informed written consent
- •Affiliation to a social security system (AME Excepted)
排除标准
- •Other criteria for PE suspicion : Acute onset of dyspnea Acute severe chest pain,
- •Pregnancy
- •Concurrent anticoagulation treatment
- •Other obvious cause of syncope : Seizure, Stroke, Traumatic brain injury , toxic intake , Atrioventricular block type 3
研究组 & 干预措施
All patient
Included patients will undergo a formal work up for pulmonary embolism: Ddimer testing, followed if positive by a computed tomography pulmonary angiogram or V/Q scan.
干预措施: Ddimer testing (Biological)
结局指标
主要结局
diagnosis of Pulmonary embolism within 72 hrs after ED visit Safety
时间窗: 72 hours after ED visit
diagnosis of Pulmonary embolism within 72 hrs after ED visit ( Ddimer testing, followed if positive by a computed tomography pulmonary angiogram or V/Q scan).
次要结局
- Validation of usual clinical decision rules-Wells(Day 0)
- Validation of usual clinical decision rules-Revised Geneva Score(Day 0)
- Validation of usual clinical decision rules-PERC(Day 0)
- Prevalence of Pulmonary Embolism among patients with cancer history.(Day 28)
- rate of false positive of the PERC rule(72 hours after ED visit)