Pulmonary inflammation during mechanical ventilation of patients with healthy lungs
Completed
- Conditions
- Mechanical ventilation, complicationsRespiratoryMechanical ventilation
- Registration Number
- ISRCTN77539853
- Lead Sponsor
- Academic Medical Centre (AMC) (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Patients that are scheduled for surgical procedure of greater than 5 hours
2. Healthy pulmonary condition
3. 18 years of age
4. Informed consent
Exclusion Criteria
1. Sepsis or uncontrolled infection
2. Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS)
3. Pneumonia
4. Steroid-use
5. Diagnosis of asthma
6. Pulmonary fibrosis
7. Current thrombo-embolism
8. On daily medication for chronic obstructive pulmonary disease (COPD)
9. Mechanical ventilation for greater than 48 hours in the month prior to surgery
10. Pneumonectomy/lebectomy
11. Participation in another trial
12. Previous randomisation in present trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Local levels of cytokines<br>2. Neutrophil influx<br>3. Activation of coagulation/inhibition of fibrinolysis<br>4. Ex vivo stimulation of alveolar macrophages<br>5. Systemic levels of biomarkers of lung injury
- Secondary Outcome Measures
Name Time Method o secondary outcome measures