Basophil degranulation assay as an in vitro model of anaphylaxis
Withdrawn
- Conditions
- Hymenoptera venom allergyinsect venom allergy10001708
- Registration Number
- NL-OMON38967
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 35
Inclusion Criteria
- A clear positive history of a systemic response grade IV or a large local reaction after a vespid sting*
- Vespid specific serum IgE > 0.70 kUA/l or a positive intracutaneous skin test for vespid venom (at <= 1 µg/ml)*
- Written informed consent
*These inclusion criteria do not apply to the indicator subjects
Exclusion Criteria
- Age under 18 years
- Incapacitated subjects
- Conditions that influence the immune system (immune deficiencies, malignancy, auto-immune diseases)
- Pregnancy (measured before inclusion by β-hCG)
- Mastocytosis;Extra exclusion criteria for indicator subjects:
- A positive history of a large local or systemic response after a Hymenoptera sting
- Vespid specific serum IgE > 0.30 kUA/l
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method