Assessment of the Relationship Between Delivery Route, Umbilical Cord pH and Fetal Complications With Doppler Parameters Measured Prior to Induction of Labor at Term Pregnancies.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- APGAR score at 5 minutes
研究概览
简要总结
Term pregnancies within their 37-41 gestational week, who were planned to undergo induction of labor, were included in the study. Prior to initiation of the induction of labor, all included pregnant women underwent an assessment of Doppler flow indices, which included fetal umblical artery PI (pulsatility index) and fetal middle cerebral artery (MCA:Middle cerebral arter) PI. Cerebroplacental Ratio (CPR) was calculated by dividing MCA PI value to umbilical artery PI (MCA PI/UA PI=CPR).Included pregnant women were categorized as Group 1 and Group 2, which comprised of those with CPR value below 1.0 and above 1.0, respectively. Route of delivery and fetal complications, described as umbilical cord pH<7.20, APGAR score at 5 minutes <7, meconium aspiration syndrome, newborn intensive care unit admission, neonatal sepsis and neonatal death.
详细描述
Term pregnancies within their 37-41 gestational week, who were planned to undergo induction of labor, were included in the study. Prior to initiation of the induction of labor, all included pregnant women underwent an assessment of Doppler flow indices, which included fetal umblical artery PI (pulsatility index) and fetal middle cerebral artery (MCA:Middle cerebral arter) PI. Cerebroplacental Ratio (CPR) was calculated by dividing MCA PI value to umbilical artery PI (MCA PI/UA PI=CPR).Included pregnant women were categorized as Group 1 and Group 2, which comprised of those with CPR value below 1.0 and above 1.0, respectively. All women who were considered appropriate for induction of labor were performed an pelvic examination and their Bishop scores were calculated. Those with a Bishop score equal to or below 5 were included in the study. Vaginal misoprostol (prostoglandin E1, 25 mcg) and dinoproston (prostoglandin E2, 10 mg) were used for induction of labor. Repeat doses were implemented in case of insufficient cervical ripening. Oxytocin was not used at the initial stages of labour, while it was used at the latter stages when necessary.
Route of delivery and fetal complications, described as umbilical cord pH<7.20, APGAR score at 5 minutes <7, meconium aspiration syndrome, newborn intensive care unit admission, neonatal sepsis and neonatal death.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Term pregnancies between 37 and 41 gestational weeks Pregnancies destined to induction of labor
排除标准
- •history of uterine scar, nonverteks presentation, multiple pregnancies, use of vacuum of forceps at delivery, shoulder dystocia, confirmed fetal structural or chromosomal anomalies
结局指标
主要结局
APGAR score at 5 minutes
时间窗: Postpartum 5 minutes
APGAR score determined by the pediatrician at postpartum 5 minutes
Newborn intensive care unit administration
时间窗: Within postpartum 1 month period
Newborn intensive care unit administration, due to a variety of conditions, which were established by pediatrician
Meconium aspiration syndrome
时间窗: Within postpartum two weeks
Meconium aspiration syndrome diagnosed by the pediatrician, either clinically or by thorax X-ray film.
Neonatal sepsis
时间窗: Within postpartum 1 month period
Neonatal sepsis diagnosed by the pediatrician
Neonatal death
时间窗: Within postpartum 1 month period
Neonatal death
Umblical arter pH
时间窗: Within 1-3 minutes following delivery
Umbilical cord blood sampling just after the delivery of the newborn and pH measurement
次要结局
- Route of delivery(At the time of delivery)
研究者
Özkan Özdamar
M.D., Principal Investigator, Clinical Investigator of OB&GYN
Istanbul Medeniyet University
