Changes in tissue glucose by diabetic ketoacidosis and obesity: Valid tissue glucose in diabetic ketoacidosis and in obesity?

Recruiting

Conditions: E10.90
E66.09

Registration Number: DRKS00012650

Lead Sponsor: Pädiatrische Endokrinologie und Diabetologie, Klinik für Allgemeine Pädiatrie, Zentrum für Kinder- und Jugendmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

1.In General:
a.Signed informed consent

2.Type 1 Diabetes with ketoacidosis
a.Ketoacidosis with pH < 7,2 and ketonuria at diagnosis
b.Age 5 - 18 years
c.Previously diagnosed type 1 diabetes or highly probable type 1 diabetes

3.Lean, healthy individuals
a.Age > 18 years
b.BMI 18,5 – 25 kg/m2

4.Obese, healthy individuals
a.Age > 18 years
b.BMI >30 kg/m2

Exclusion Criteria

1.In general:
a.BMI < 18,5 kg/m2 (adults), < 3. age adjusted percentile (children, adolescents)
b.Medication with salicylic acid or Vitamin C

2.Type 1 diabetes in ketoacidosis
a.Mechanic ventilation or therapy with catecholamines
b.Cerebral edema

3.Lean, healthy individuals
a.Planned MRI during study

4.Obese healthy individuals
a.Planned MRI during study

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Concurrence of blood glucose and tissue glucose in patients with ketoacidosis by comparison of blood glucose and tissue glucose results that were mesured during the inpatient stay (up to 14 days). <br><br>Concurrence of blood glucose and tissue glucose in lean and obese healthy individuals during 72 hours and during an oral glucose tolerance test by measurement of blood glucose and tissue glucose with the freestyle libre device. <br><br>

Secondary Outcome Measures

Name	Time	Method
•Interference of measurements by pH, Bicarbonate, Exsiccosis (weight loss, base excess), derangement of electrolytes, measured by blood gas anaylses and weighing during the inpatient stay. Timepoints are set by clinical necessity. <br><br><br>•Delay by obesity, determined by repetitive measurement in set time frames (+30 minutes) after blood glucose measurements and during oral glucose tolerance testing. <br><br>